Curated Information
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Home > Curated Information Page > PubMed Id: 24159092
Reddy VS, et al. (2013) Response of small heat shock proteins in diabetic rat retina. Invest Ophthalmol Vis Sci 54, 7674-82 24159092
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S19-p - CRYAB (rat)
Modsite: RPFFPFHsPSRLFDQ SwissProt Entrez-Gene
Orthologous residues
CRYAB (human): S19‑p, CRYAB (mouse): S19‑p, CRYAB (rat): S19‑p, CRYAB (rabbit): S19‑p, CRYAB (pig): S19‑p, CRYAB (cow): S19‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
diabetes increase
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  signaling pathway regulation
Comments:  localization of phosphorylated alpha-BCs in the diabetic retina

S45-p - CRYAB (rat)
Modsite: FSTATSLsPFYLRPP SwissProt Entrez-Gene
Orthologous residues
CRYAB (human): S45‑p, CRYAB (mouse): S45‑p, CRYAB (rat): S45‑p, CRYAB (rabbit): S45‑p, CRYAB (pig): S45‑p, CRYAB (cow): S45‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
diabetes increase
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  signaling pathway regulation
Comments:  localization of phosphorylated alpha-BCs in the diabetic retina

S59-p - CRYAB (rat)
Modsite: PSFLRAPsWIDTGLS SwissProt Entrez-Gene
Orthologous residues
CRYAB (human): S59‑p, CRYAB (mouse): S59‑p, CRYAB (rat): S59‑p, CRYAB (rabbit): S59‑p, CRYAB (pig): S59‑p, CRYAB (cow): S59‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
diabetes decrease soluble fraction
diabetes increase insoluble fraction
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  signaling pathway regulation
Comments:  localization of phosphorylated alpha-BCs in the diabetic retina

T180-p - P38A (rat)
Modsite: RHTDDEMtGyVATRW SwissProt Entrez-Gene
Orthologous residues
P38A (human): T180‑p, P38A iso2 (human): T180‑p, P38A (mouse): T180‑p, P38A iso3 (mouse): T180‑p, P38A (rat): T180‑p, P38A (salmonid): T181‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
diabetes increase

Y182-p - P38A (rat)
Modsite: TDDEMtGyVATRWYR SwissProt Entrez-Gene
Orthologous residues
P38A (human): Y182‑p, P38A iso2 (human): Y182‑p, P38A (mouse): Y182‑p, P38A iso3 (mouse): Y182‑p, P38A (rat): Y182‑p, P38A (salmonid): Y183‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
diabetes increase