Curated Information
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Home > Curated Information Page > PubMed Id: 24116014
Kooij V, et al. (2013) PKCĪ±-Specific Phosphorylation of the Troponin Complex in Human Myocardium: A Functional and Proteomics Analysis. PLoS One 8, e74847 24116014
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S23-p - TNNI3 (human)
Modsite: PAPIRRRssNyRAyA SwissProt Entrez-Gene
Orthologous residues
TNNI3 (human): S23‑p, TNNI3 (mouse): S23‑p, TNNI3 (rat): S23‑p, TNNI3 (rabbit): S22‑p, TNNI3 (dog): S23‑p, TNNI3 (cow): S24‑p
Downstream Regulation
Effect of modification (function):  activity, inhibited
Comments:  reduced maximal force generation

S24-p - TNNI3 (human)
Modsite: APIRRRssNyRAyAt SwissProt Entrez-Gene
Orthologous residues
TNNI3 (human): S24‑p, TNNI3 (mouse): S24‑p, TNNI3 (rat): S24‑p, TNNI3 (rabbit): S23‑p, TNNI3 (dog): S24‑p, TNNI3 (cow): S25‑p
Downstream Regulation
Effect of modification (function):  activity, inhibited
Comments:  reduced maximal force generation

S42-p - TNNI3 (human)
Modsite: AKKKskIsAsRKLQL SwissProt Entrez-Gene
Orthologous residues
TNNI3 (human): S42‑p, TNNI3 (mouse): S43‑p, TNNI3 (rat): S43‑p, TNNI3 (rabbit): S42‑p, TNNI3 (dog): S43‑p, TNNI3 (cow): S44‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  tissue
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (human)
Downstream Regulation
Effect of modification (function):  activity, inhibited
Comments:  reduced maximal force generation

S44-p - TNNI3 (human)
Modsite: KKskIsAsRKLQLKt SwissProt Entrez-Gene
Orthologous residues
TNNI3 (human): S44‑p, TNNI3 (mouse): S45‑p, TNNI3 (rat): S45‑p, TNNI3 (rabbit): S44‑p, TNNI3 (dog): S45‑p, TNNI3 (cow): S46‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  tissue
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (human)
Downstream Regulation
Effect of modification (function):  activity, inhibited
Comments:  reduced maximal force generation

T143-p - TNNI3 (human)
Modsite: RGKFKRPtLRRVrIs SwissProt Entrez-Gene
Orthologous residues
TNNI3 (human): T143‑p, TNNI3 (mouse): T144‑p, TNNI3 (rat): T144‑p, TNNI3 (rabbit): T143‑p, TNNI3 (dog): T144‑p, TNNI3 (cow): T145‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  tissue
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (human)
Downstream Regulation
Effect of modification (function):  activity, inhibited
Comments:  reduced maximal force generation

S199-p - TNNI3 (human)
Modsite: RKNIDALsGMEGRKK SwissProt Entrez-Gene
Orthologous residues
TNNI3 (human): S199‑p, TNNI3 (mouse): S200‑p, TNNI3 (rat): S200‑p, TNNI3 (rabbit): S200‑p, TNNI3 (dog): S200‑p, TNNI3 (cow): S201‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  tissue
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (human)
Downstream Regulation
Effect of modification (function):  activity, inhibited
Comments:  reduced maximal force generation

S189-p - TNNT2 (human)
Modsite: ARKKKALsNMMHFGG SwissProt Entrez-Gene
Orthologous residues
TNNT2 (human): S189‑p, TNNT2 (mouse): S192‑p, TNNT2 iso2 (mouse): S182‑p, TNNT2 (rat): S191‑p, TNNT2 iso2 (rat): S181‑p, TNNT2 (rabbit): S192‑p, TNNT2 (cow): S177‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  tissue
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (human)