Ohama T, Wang L, Griner EM, Brautigan DL (2013) Protein Ser/Thr phosphatase-6 is required for maintenance of E-cadherin at adherens junctions. BMC Cell Biol 14, 42 24063632

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S846-p - CDH1 (mouse) ▲

Modsite: GsGsEAAsLssLNSs SwissProt Entrez-Gene Orthologous residues CDH1 (human): S844‑p, CDH1 (mouse): S846‑p, CDH1 (rat): S848‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  colorectal cancer, colorectal carcinoma Relevant cell lines - cell types - tissues:  Caco-2 (intestinal) Cellular systems studied:  cell lines Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes PPP6C (mouse) decrease Downstream Regulation Effect of modification (function):  intracellular localization Comments:  internalization of E-cadherin off the cell surface