Curated Information
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Home > Curated Information Page > PubMed Id: 14679215
Zheng Q, et al. (2004) 14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function. J Biol Chem 279, 8787-91 14679215
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S486-p - ERK5 (mouse)
Modsite: LKAALLKsLRSRLRD SwissProt Entrez-Gene
Orthologous residues
ERK5 (human): S486‑p, ERK5 iso2 (human): S347‑p, ERK5 (mouse): S486‑p, ERK5 (rat): S486‑p
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  enzymatic activity, inhibited, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
14-3-3 beta (mouse) Induces