Qiu Y, Law PY, Loh HH (2003) Mu-opioid receptor desensitization: role of receptor phosphorylation, internalization, and representation. J Biol Chem 278, 36733-9 12860981

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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T370-p - MOR-1 (rat) ▲

Modsite: sTRVRQNtREHPsTA SwissProt Entrez-Gene Orthologous residues MOR‑1 (human): T372‑p, MOR‑1 iso5 (human): T372‑p, MOR‑1 (mouse): T370‑p, MOR‑1 (rat): T370‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  Neuro-2a (neuron) Cellular systems studied:  cell lines Species studied:  mouse Comments:  truncation mutant Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes etorphine increase Downstream Regulation Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered Comments:  truncation that deletes T370, S375 and T394 alters kinetics of receptor internalization and desensitization

S375-p - MOR-1 (rat) ▲

Modsite: QNtREHPsTANTVDR SwissProt Entrez-Gene Orthologous residues MOR‑1 (human): S377‑p, MOR‑1 iso5 (human): S377‑p, MOR‑1 (mouse): S375‑p, MOR‑1 (rat): S375‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  Neuro-2a (neuron) Cellular systems studied:  cell lines Species studied:  mouse Comments:  truncation mutant Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes etorphine increase Downstream Regulation Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered Comments:  truncation that deletes T370, S375 and T394 alters kinetics of receptor internalization and desensitization

T394-p - MOR-1 (rat) ▲

Modsite: LENLEAEtAPLP___ SwissProt Entrez-Gene Orthologous residues MOR‑1 (human): T396‑p, MOR‑1 iso5 (human): M395‑p, MOR‑1 (mouse): T394‑p, MOR‑1 (rat): T394‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  Neuro-2a (neuron) Cellular systems studied:  cell lines Species studied:  mouse Comments:  truncation mutant Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes etorphine increase Downstream Regulation Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered Comments:  truncation that deletes T370, S375 and T394 alters kinetics of receptor internalization and desensitization