Curated Information
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Home > Curated Information Page > PubMed Id: 10559276
Wang Z, Danielsen AJ, Maihle NJ, McManus MJ (1999) Tyrosine phosphorylation of caldesmon is required for binding to the Shc.Grb2 complex. J Biol Chem 274, 33807-13 10559276
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y27-p - Caldesmon (chicken)
Modsite: LEAERLsyQRNDDDE SwissProt Entrez-Gene
Orthologous residues
Caldesmon (human): Y27‑p, Caldesmon iso2 (human): Y27‑p, Caldesmon iso3 (human): Y21‑p, Caldesmon iso4 (human): Y27‑p, Caldesmon iso5 (human): Y21‑p, Caldesmon iso6 (human): Y27‑p, Caldesmon (mouse): Y27‑p, Caldesmon iso5 (mouse): Y21‑p, Caldesmon (rat): Y21‑p, Caldesmon (rabbit): Y27‑p, Caldesmon (chicken): Y27‑p, Caldesmon (cow): Y27‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGFR (human) increase v-erbB
Phosphorylation of this residue was observed only in cells expressing S3-v-Erb2
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHC1 (human) Induces not reported co-immunoprecipitation

Y640-p - Caldesmon (chicken)
Modsite: IDsRLEQyTsAVVGN SwissProt Entrez-Gene
Orthologous residues
Caldesmon (human): Y682‑p, Caldesmon iso2 (human): Y453‑p, Caldesmon iso3 (human): Y447‑p, Caldesmon iso4 (human): Y427‑p, Caldesmon iso5 (human): Y421‑p, Caldesmon iso6 (human): Y452‑p, Caldesmon (mouse): Y657‑p, Caldesmon iso5 (mouse): Y419‑p, Caldesmon (rat): Y420‑p, Caldesmon (rabbit): Y422‑p, Caldesmon (chicken): Y640‑p, Caldesmon (cow): Y424‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGFR (human) increase v-erbB