Wasylishen AR, et al. (2013) MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity. Cancer Res 73, 6504-15 24030976

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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T73-p - Myc (human) ▲

Modsite: kkFELLPtPPLsPsR SwissProt Entrez-Gene Orthologous residues Myc (human): T73‑p, Myc iso1 (human): T58‑p, Myc (mouse): T73‑p, Myc (rat): T72‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  MCF10A1 (epithelial), SHEP (neuron) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  carcinogenesis, inhibited, transcription, inhibited

S77-p - Myc (human) ▲

Modsite: LLPtPPLsPsRRsGL SwissProt Entrez-Gene Orthologous residues Myc (human): S77‑p, Myc iso1 (human): S62‑p, Myc (mouse): S77‑p, Myc (rat): S76‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  MCF10A1 (epithelial), SHEP (neuron) Cellular systems studied:  cell lines Species studied:  human

S86-p - Myc (human) ▲

Modsite: sRRsGLCsPSyVAVt SwissProt Entrez-Gene Orthologous residues Myc (human): S86‑p, Myc iso1 (human): S71‑p, Myc (mouse): S86‑p, Myc (rat): S85‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  MCF10A1 (epithelial), SHEP (neuron) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  carcinogenesis, inhibited, transcription, inhibited

S96-p - Myc (human) ▲

Modsite: yVAVtPFsLRGDNDG SwissProt Entrez-Gene Orthologous residues Myc (human): S96‑p, Myc iso1 (human): S81‑p, Myc (mouse): S97‑p, Myc (rat): S96‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  MCF10A1 (epithelial), SHEP (neuron) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  carcinogenesis, inhibited, transcription, inhibited

T358-p - Myc (human) ▲

Modsite: IsNNRKCtsPrssDt SwissProt Entrez-Gene Orthologous residues Myc (human): T358‑p, Myc iso1 (human): T343‑p, Myc (mouse): S358‑p, Myc (rat): S357‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  MCF10A1 (epithelial), SHEP (neuron) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  carcinogenesis, inhibited, transcription, inhibited

S359-p - Myc (human) ▲

Modsite: sNNRKCtsPrssDtE SwissProt Entrez-Gene Orthologous residues Myc (human): S359‑p, Myc iso1 (human): S344‑p, Myc (mouse): S359‑p, Myc (rat): S358‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  MCF10A1 (epithelial), SHEP (neuron) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  carcinogenesis, inhibited, transcription, inhibited

S362-p - Myc (human) ▲

Modsite: RKCtsPrssDtEENV SwissProt Entrez-Gene Orthologous residues Myc (human): S362‑p, Myc iso1 (human): S347‑p, Myc (mouse): S362‑p, Myc (rat): S361‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  MCF10A1 (epithelial), SHEP (neuron) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  carcinogenesis, inhibited, transcription, inhibited

S363-p - Myc (human) ▲

Modsite: KCtsPrssDtEENVk SwissProt Entrez-Gene Orthologous residues Myc (human): S363‑p, Myc iso1 (human): S348‑p, Myc (mouse): S363‑p, Myc (rat): S362‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  MCF10A1 (epithelial), SHEP (neuron) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  carcinogenesis, inhibited, transcription, inhibited