Curated Information
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Home > Curated Information Page > PubMed Id: 24023254
Kim do K, et al. (2013) The scaffold protein prohibitin is required for antigen-stimulated signaling in mast cells. Sci Signal 6, ra80 24023254
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y114-p - PHB (mouse)
Modsite: YTsIGEDyDERVLPS SwissProt Entrez-Gene
Orthologous residues
PHB (human): Y114‑p, PHB (mouse): Y114‑p, PHB (rat): Y114‑p, PHB (pig): Y114‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE LYN (mouse) siRNA inhibition of enzyme, pharmacological inhibitor of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
antigenic stimulation increase
PP2 decrease
siRNA decrease siRNA for Lyn decreases phosphorylation
Downstream Regulation
Effect of modification (function):  intracellular localization, molecular association, regulation
Effect of modification (process):  signaling pathway regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
FCER1G (mouse) Induces co-immunoprecipitation
Comments:  FCER1G and Syk-mediated signaling, increases antigen-induced mast cell degranulation

Y259-p - PHB (mouse)
Modsite: SRSRNItyLPAGQsV SwissProt Entrez-Gene
Orthologous residues
PHB (human): Y259‑p, PHB (mouse): Y259‑p, PHB (rat): Y259‑p, PHB (pig): Y259‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE LYN (mouse) siRNA inhibition of enzyme, pharmacological inhibitor of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
antigenic stimulation increase
PP2 decrease
siRNA decrease siRNA for Lyn decreases phosphorylation
Downstream Regulation
Effect of modification (function):  intracellular localization, molecular association, regulation
Effect of modification (process):  signaling pathway regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
FCER1G (mouse) Induces co-immunoprecipitation
Comments:  FCER1G and Syk-mediated signaling, increases antigen-induced mast cell degranulation