Yeh C, et al. (2013) IGF-1 Activates a Cilium-Localized Noncanonical Gβγ Signaling Pathway that Regulates Cell-Cycle Progression. Dev Cell 26, 358-68 23954591

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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T94-p - DYNLT1 (human) ▲

Modsite: SSTDGSCtVRWENKT SwissProt Entrez-Gene Orthologous residues DYNLT1 (human): T94‑p, DYNLT1 (mouse): T94‑p, DYNLT1 (rat): T94‑p, DYNLT1 (cow): T94‑p Characterization Methods used to characterize site in vivo:  immunoassay, mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  3T3 (fibroblast), hTERT-RPE1 (epithelial), neuron-'brain, cerebral cortex' Cellular systems studied:  cell lines Species studied:  human, mouse Downstream Regulation Effect of modification (function):  intracellular localization Effect of modification (process):  cell cycle regulation, cell differentiation, induced, cell growth, induced Comments:  T94 phosphorylation promotes proliferation of neural progenitors through modulation of ciliary resorption and G1 length.

T94-p - DYNLT1 (mouse) ▲

Modsite: SSTDGSCtVRWENkT SwissProt Entrez-Gene Orthologous residues DYNLT1 (human): T94‑p, DYNLT1 (mouse): T94‑p, DYNLT1 (rat): T94‑p, DYNLT1 (cow): T94‑p Characterization Methods used to characterize site in vivo:  immunoassay, mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  3T3 (fibroblast), hTERT-RPE1 (epithelial), neuron-'brain, cerebral cortex' Cellular systems studied:  cell lines Species studied:  human, mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes IGF-1 increase antibody IGF-1 inhibit treatment-induced increase alphaIR3; anti-IGF1R Downstream Regulation Effect of modification (function):  activity, induced, intracellular localization Effect of modification (process):  cell cycle regulation, cell differentiation, induced, cell growth, induced Comments:  ciliary resorption, T94 phosphorylation promotes proliferation of neural progenitors through modulation of ciliary resorption and G1 length.

Y1163-p - IGF1R (mouse) ▲

Modsite: FGMTRDIyEtDyyRK SwissProt Entrez-Gene Orthologous residues IGF1R (human): Y1161‑p, IGF1R (mouse): Y1163‑p, IGF1R (rat): Y1162‑p, IGF1R (pig): Y1161‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Relevant cell lines - cell types - tissues:  hTERT-RPE1 (epithelial), neuron-'brain, cerebral cortex' Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes serum_starvation, IGF-1 increase Downstream Regulation Effect of modification (function):  intracellular localization Effect of modification (process):  cell cycle regulation, cell differentiation, induced, cell growth, induced Comments:  T94 phosphorylation promotes proliferation of neural progenitors through modulation of ciliary resorption and G1 length.

Y1167-p - IGF1R (mouse) ▲

Modsite: RDIyEtDyyRKGGkG SwissProt Entrez-Gene Orthologous residues IGF1R (human): Y1165‑p, IGF1R (mouse): Y1167‑p, IGF1R (rat): Y1166‑p, IGF1R (pig): Y1165‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Relevant cell lines - cell types - tissues:  hTERT-RPE1 (epithelial), neuron-'brain, cerebral cortex' Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes serum_starvation, IGF-1 increase Downstream Regulation Effect of modification (function):  intracellular localization Effect of modification (process):  cell cycle regulation, cell differentiation, induced, cell growth, induced Comments:  T94 phosphorylation promotes proliferation of neural progenitors through modulation of ciliary resorption and G1 length.

Y1168-p - IGF1R (mouse) ▲

Modsite: DIyEtDyyRKGGkGL SwissProt Entrez-Gene Orthologous residues IGF1R (human): Y1166‑p, IGF1R (mouse): Y1168‑p, IGF1R (rat): Y1167‑p, IGF1R (pig): Y1166‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Relevant cell lines - cell types - tissues:  hTERT-RPE1 (epithelial), neuron-'brain, cerebral cortex' Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes serum_starvation, IGF-1 increase Downstream Regulation Effect of modification (function):  intracellular localization Effect of modification (process):  cell cycle regulation, cell differentiation, induced, cell growth, induced Comments:  T94 phosphorylation promotes proliferation of neural progenitors through modulation of ciliary resorption and G1 length.