Yun HJ, et al. (2013) LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25. Exp Mol Med 45, e36 23949442

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T117-p - SNAPIN (human) ▲

Modsite: NHsVAKEtARRRAML SwissProt Entrez-Gene Orthologous residues SNAPIN (human): T117‑p, SNAPIN (mouse): T117‑p, SNAPIN (rat): T117‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE LRRK2 (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE LRRK2 (human) co-immunoprecipitation Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  exocytosis, inhibited Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays SNAP-25 (human) Disrupts molecular association, regulation pull-down assay, co-immunoprecipitation