Sakurai T, Tsuchida M, Lampe PD, Murakami M (2013) Cardiomyocyte FGF signaling is required for Cx43 phosphorylation and cardiac gap junction maintenance. Exp Cell Res 319, 2152-65 23742896

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S325-p - GJA1 (rat) ▲

Modsite: NRMGQAGstIsNsHA SwissProt Entrez-Gene Orthologous residues GJA1 (human): S325‑p, GJA1 (mouse): S325‑p, GJA1 (rat): S325‑p, GJA1 (rabbit): S325‑p, GJA1 (pig): S325‑p, GJA1 (hamster): S325‑p, GJA1 (cow): S326‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  COS7 (fibroblast), myocyte-heart Cellular systems studied:  primary cultured cells Species studied:  green monkey, rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes FGFR1 (rat) decrease dominant-negative mutant Downstream Regulation Effect of modification (process):  cell adhesion, induced, signaling pathway regulation Comments:  cardiomyocyte FGF signaling, maintenance of cell-cell gap junctions

S328-p - GJA1 (rat) ▲

Modsite: GQAGstIsNsHAQPF SwissProt Entrez-Gene Orthologous residues GJA1 (human): S328‑p, GJA1 (mouse): S328‑p, GJA1 (rat): S328‑p, GJA1 (rabbit): S328‑p, GJA1 (pig): S328‑p, GJA1 (hamster): S328‑p, GJA1 (cow): S329‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  COS7 (fibroblast), myocyte-heart Cellular systems studied:  primary cultured cells Species studied:  green monkey, rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes FGFR1 (rat) decrease dominant-negative mutant Downstream Regulation Effect of modification (process):  cell adhesion, induced, signaling pathway regulation Comments:  cardiomyocyte FGF signaling, maintenance of cell-cell gap junctions

S330-p - GJA1 (rat) ▲

Modsite: AGstIsNsHAQPFDF SwissProt Entrez-Gene Orthologous residues GJA1 (human): S330‑p, GJA1 (mouse): S330‑p, GJA1 (rat): S330‑p, GJA1 (rabbit): S330‑p, GJA1 (pig): S330‑p, GJA1 (hamster): S330‑p, GJA1 (cow): S331‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  COS7 (fibroblast), myocyte-heart Cellular systems studied:  primary cultured cells Species studied:  green monkey, rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes FGFR1 (rat) decrease dominant-negative mutant Downstream Regulation Effect of modification (process):  cell adhesion, induced, signaling pathway regulation Comments:  cardiomyocyte FGF signaling, maintenance of cell-cell gap junctions

S365-p - GJA1 (rat) ▲

Modsite: IVDQRPssRAssRAs SwissProt Entrez-Gene Orthologous residues GJA1 (human): S365‑p, GJA1 (mouse): S365‑p, GJA1 (rat): S365‑p, GJA1 (rabbit): S365‑p, GJA1 (pig): S365‑p, GJA1 (hamster): S365‑p, GJA1 (cow): S366‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  myocyte-heart Cellular systems studied:  primary cultured cells Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes FGFR1 (rat) decrease dominant-negative mutant