Curated Information
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Home > Curated Information Page > PubMed Id: 17634293
Muresan Z, Muresan V (2007) The amyloid-beta precursor protein is phosphorylated via distinct pathways during differentiation, mitosis, stress, and degeneration. Mol Biol Cell 18, 3835-44 17634293
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T729-p - APP (human)
Modsite: MLkkkQytsIHHGVV SwissProt Entrez-Gene
Orthologous residues
APP (human): T729‑p, APP iso4 (human): T654‑p, APP iso8 (human): T710‑p, APP iso10 (human): T598‑p, APP (mouse): T729‑p, APP iso2 (mouse): T654‑p, APP (rat): T729‑p, APP iso2 (rat): T654‑p
Associated Diseases
Diseases Alterations Comments
Alzheimer's disease increased

T743-p - APP (human)
Modsite: VEVDAAVtPEERHLS SwissProt Entrez-Gene
Orthologous residues
APP (human): T743‑p, APP iso4 (human): T668‑p, APP iso8 (human): T724‑p, APP iso10 (human): T612‑p, APP (mouse): T743‑p, APP iso2 (mouse): T668‑p, APP (rat): T743‑p, APP iso2 (rat): T668‑p
Characterization
Methods used to characterize site in vivo microscopy-colocalization with upstream kinase, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  CAD (neuron)
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
sorbitol increase
SB415286 decrease
SP600125 decrease
seliciclib decrease
Downstream Regulation
Effect of modification (function):  intracellular localization, protein stabilization
Comments:  localizes in endosomes in distal neurites

T183-p - JNK1 (human)
Modsite: AGtsFMMtPyVVtRY SwissProt Entrez-Gene
Orthologous residues
JNK1 (human): T183‑p, JNK1 iso2 (human): T183‑p, JNK1 iso3 (human): T183‑p, JNK1 (mouse): T183‑p, JNK1 (rat): T183‑p
Characterization
Methods used to characterize site in vivo microscopy-colocalization with upstream kinase, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  CAD (neuron)
Cellular systems studied:  cell lines
Species studied:  mouse

Y185-p - JNK1 (human)
Modsite: tsFMMtPyVVtRYYR SwissProt Entrez-Gene
Orthologous residues
JNK1 (human): Y185‑p, JNK1 iso2 (human): Y185‑p, JNK1 iso3 (human): Y185‑p, JNK1 (mouse): Y185‑p, JNK1 (rat): Y185‑p
Characterization
Methods used to characterize site in vivo microscopy-colocalization with upstream kinase, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  CAD (neuron)
Cellular systems studied:  cell lines
Species studied:  mouse

T183-p - JNK2 (human)
Modsite: ACtNFMMtPyVVtRY SwissProt Entrez-Gene
Orthologous residues
JNK2 (human): T183‑p, JNK2 iso2 (human): T183‑p, JNK2 iso3 (human): T183‑p, JNK2 (mouse): T183‑p, JNK2 (rat): T183‑p
Characterization
Methods used to characterize site in vivo microscopy-colocalization with upstream kinase, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  CAD (neuron)
Cellular systems studied:  cell lines
Species studied:  mouse

Y185-p - JNK2 (human)
Modsite: tNFMMtPyVVtRYYR SwissProt Entrez-Gene
Orthologous residues
JNK2 (human): Y185‑p, JNK2 iso2 (human): Y185‑p, JNK2 iso3 (human): Y185‑p, JNK2 (mouse): Y185‑p, JNK2 (rat): Y185‑p
Characterization
Methods used to characterize site in vivo microscopy-colocalization with upstream kinase, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  CAD (neuron)
Cellular systems studied:  cell lines
Species studied:  mouse