Jeffers MF (1999) Activating mutations in the Met receptor overcome the requirement for autophosphorylation of tyrosines crucial for wild type signaling. Oncogene 18, 5120-5 10490849

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Y1234-p - Met (human) ▲

Modsite: RDMyDkEyysVHNkt SwissProt Entrez-Gene Orthologous residues Met (human): Y1234‑p, Met iso2 (human): Y1252‑p, Met (mouse): Y1232‑p, Met (rat): Y1235‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  3T3 (fibroblast) Cellular systems studied:  cell lines Species studied:  mouse Downstream Regulation Effect of modification (function):  enzymatic activity, induced Effect of modification (process):  cell growth, altered

Y1235-p - Met (human) ▲

Modsite: DMyDkEyysVHNktG SwissProt Entrez-Gene Orthologous residues Met (human): Y1235‑p, Met iso2 (human): Y1253‑p, Met (mouse): Y1233‑p, Met (rat): Y1236‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  3T3 (fibroblast) Cellular systems studied:  cell lines Species studied:  mouse Downstream Regulation Effect of modification (function):  enzymatic activity, induced Effect of modification (process):  cell growth, altered

Y1349-p - Met (human) ▲

Modsite: stFIGEHyVHVNAty SwissProt Entrez-Gene Orthologous residues Met (human): Y1349‑p, Met iso2 (human): Y1367‑p, Met (mouse): Y1347‑p, Met (rat): Y1350‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  3T3 (fibroblast) Cellular systems studied:  cell lines Species studied:  mouse Downstream Regulation Effect of modification (process):  cell growth, altered

Y1356-p - Met (human) ▲

Modsite: yVHVNAtyVNVKCVA SwissProt Entrez-Gene Orthologous residues Met (human): Y1356‑p, Met iso2 (human): Y1374‑p, Met (mouse): Y1354‑p, Met (rat): Y1357‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  3T3 (fibroblast) Cellular systems studied:  cell lines Species studied:  mouse Downstream Regulation Effect of modification (process):  cell growth, altered