Curated Information
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Home > Curated Information Page > PubMed Id: 10069803
Tulasne D, et al. (1999) The multisubstrate docking site of the MET receptor is dispensable for MET-mediated RAS signaling and cell scattering. Mol Biol Cell 10, 551-65 10069803
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y1311-p - Met (mouse)
Modsite: EYCPDALyEVMLKCW SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1313‑p, Met iso2 (human): Y1331‑p, Met (mouse): Y1311‑p, Met (rat): Y1314‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  MDCK (epithelial)
Cellular systems studied:  cell lines
Species studied:  dog
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cytoskeletal reorganization
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHC1 (mouse) Induces co-immunoprecipitation
GRB2 (mouse) Induces co-immunoprecipitation
GAB1 (mouse) Induces co-immunoprecipitation
PIK3C2A (mouse) Induces co-immunoprecipitation

Y1347-p - Met (mouse)
Modsite: STFIGEHyVHVNATy SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1349‑p, Met iso2 (human): Y1367‑p, Met (mouse): Y1347‑p, Met (rat): Y1350‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  MDCK (epithelial)
Cellular systems studied:  cell lines
Species studied:  dog
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cytoskeletal reorganization
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
GRB2 (mouse) Induces co-immunoprecipitation
SHC1 (mouse) Induces co-immunoprecipitation
PIK3C2A (mouse) Induces co-immunoprecipitation
GAB1 (mouse) Induces co-immunoprecipitation

Y1354-p - Met (mouse)
Modsite: yVHVNATyVNVKCVA SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1356‑p, Met iso2 (human): Y1374‑p, Met (mouse): Y1354‑p, Met (rat): Y1357‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  MDCK (epithelial)
Cellular systems studied:  cell lines
Species studied:  dog
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cytoskeletal reorganization
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3C2A (mouse) Induces co-immunoprecipitation
SHC1 (mouse) Induces co-immunoprecipitation
GRB2 (mouse) Induces co-immunoprecipitation
GAB1 (mouse) Induces co-immunoprecipitation

Y1363-p - Met (mouse)
Modsite: NVKCVAPyPSLLPSQ SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1365‑p, Met iso2 (human): Y1383‑p, Met (mouse): Y1363‑p, Met (rat): Y1366‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  MDCK (epithelial)
Cellular systems studied:  cell lines
Species studied:  dog
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cytoskeletal reorganization
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHC1 (mouse) Induces co-immunoprecipitation
GRB2 (mouse) Induces co-immunoprecipitation
PIK3C2A (mouse) Induces co-immunoprecipitation
GAB1 (mouse) Induces co-immunoprecipitation