Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 7708691
Weidner KM, Sachs M, Riethmacher D, Birchmeier W (1995) Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells. Proc Natl Acad Sci U S A 92, 2597-601 7708691
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
Download

Y1001-p - Met (mouse)
Modsite: VsNEsVDyRATFPED SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1003‑p, Met iso2 (human): Y1021‑p, Met (mouse): Y1001‑p, Met (rat): Y1004‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  MDCK (epithelial)
Cellular systems studied:  cell lines
Species studied:  dog

Y1232-p - Met (mouse)
Modsite: rDMyDKEyysVHNKt SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1234‑p, Met iso2 (human): Y1252‑p, Met (mouse): Y1232‑p, Met (rat): Y1235‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  MDCK (epithelial)
Cellular systems studied:  cell lines
Species studied:  dog
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Met (mouse) activation of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NGF increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Comments:  necessary for autophosphorylation

Y1233-p - Met (mouse)
Modsite: DMyDKEyysVHNKtG SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1235‑p, Met iso2 (human): Y1253‑p, Met (mouse): Y1233‑p, Met (rat): Y1236‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  MDCK (epithelial)
Cellular systems studied:  cell lines
Species studied:  dog
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Met (mouse) activation of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NGF increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Comments:  necessary for autophosphorylation

Y1311-p - Met (mouse)
Modsite: EYCPDALyEVMLKCW SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1313‑p, Met iso2 (human): Y1331‑p, Met (mouse): Y1311‑p, Met (rat): Y1314‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  MDCK (epithelial)
Cellular systems studied:  cell lines
Species studied:  dog

Y1347-p - Met (mouse)
Modsite: STFIGEHyVHVNATy SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1349‑p, Met iso2 (human): Y1367‑p, Met (mouse): Y1347‑p, Met (rat): Y1350‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  MDCK (epithelial)
Cellular systems studied:  cell lines
Species studied:  dog

Y1354-p - Met (mouse)
Modsite: yVHVNATyVNVKCVA SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1356‑p, Met iso2 (human): Y1374‑p, Met (mouse): Y1354‑p, Met (rat): Y1357‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  MDCK (epithelial)
Cellular systems studied:  cell lines
Species studied:  dog

Y1363-p - Met (mouse)
Modsite: NVKCVAPyPSLLPSQ SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1365‑p, Met iso2 (human): Y1383‑p, Met (mouse): Y1363‑p, Met (rat): Y1366‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  MDCK (epithelial)
Cellular systems studied:  cell lines
Species studied:  dog