Weidner KM, Sachs M, Riethmacher D, Birchmeier W (1995) Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells. Proc Natl Acad Sci U S A 92, 2597-601 7708691

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

Download

Y1001-p - Met (mouse) ▲

Modsite: VsNEsVDyRATFPED SwissProt Entrez-Gene Orthologous residues Met (human): Y1003‑p, Met iso2 (human): Y1021‑p, Met (mouse): Y1001‑p, Met (rat): Y1004‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  MDCK (epithelial) Cellular systems studied:  cell lines Species studied:  dog

Y1232-p - Met (mouse) ▲

Modsite: rDMyDKEyysVHNKt SwissProt Entrez-Gene Orthologous residues Met (human): Y1234‑p, Met iso2 (human): Y1252‑p, Met (mouse): Y1232‑p, Met (rat): Y1235‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  MDCK (epithelial) Cellular systems studied:  cell lines Species studied:  dog Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE Met (mouse) activation of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes NGF increase Downstream Regulation Effect of modification (function):  enzymatic activity, induced Comments:  necessary for autophosphorylation

Y1233-p - Met (mouse) ▲

Modsite: DMyDKEyysVHNKtG SwissProt Entrez-Gene Orthologous residues Met (human): Y1235‑p, Met iso2 (human): Y1253‑p, Met (mouse): Y1233‑p, Met (rat): Y1236‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  MDCK (epithelial) Cellular systems studied:  cell lines Species studied:  dog Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE Met (mouse) activation of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes NGF increase Downstream Regulation Effect of modification (function):  enzymatic activity, induced Comments:  necessary for autophosphorylation

Y1311-p - Met (mouse) ▲

Modsite: EYCPDALyEVMLKCW SwissProt Entrez-Gene Orthologous residues Met (human): Y1313‑p, Met iso2 (human): Y1331‑p, Met (mouse): Y1311‑p, Met (rat): Y1314‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  MDCK (epithelial) Cellular systems studied:  cell lines Species studied:  dog

Y1347-p - Met (mouse) ▲

Modsite: STFIGEHyVHVNATy SwissProt Entrez-Gene Orthologous residues Met (human): Y1349‑p, Met iso2 (human): Y1367‑p, Met (mouse): Y1347‑p, Met (rat): Y1350‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  MDCK (epithelial) Cellular systems studied:  cell lines Species studied:  dog

Y1354-p - Met (mouse) ▲

Modsite: yVHVNATyVNVKCVA SwissProt Entrez-Gene Orthologous residues Met (human): Y1356‑p, Met iso2 (human): Y1374‑p, Met (mouse): Y1354‑p, Met (rat): Y1357‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  MDCK (epithelial) Cellular systems studied:  cell lines Species studied:  dog

Y1363-p - Met (mouse) ▲

Modsite: NVKCVAPyPSLLPSQ SwissProt Entrez-Gene Orthologous residues Met (human): Y1365‑p, Met iso2 (human): Y1383‑p, Met (mouse): Y1363‑p, Met (rat): Y1366‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  MDCK (epithelial) Cellular systems studied:  cell lines Species studied:  dog