Curated Information
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Home > Curated Information Page > PubMed Id: 10619845
Herbst R, Burden SJ (2000) The juxtamembrane region of MuSK has a critical role in agrin-mediated signaling. EMBO J 19, 67-77 10619845
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y553-p - MUSK (mouse)
Modsite: RLHPNPMyQRMPLLL SwissProt Entrez-Gene
Orthologous residues
MUSK (human): Y554‑p, MUSK (mouse): Y553‑p, MUSK (rat): Y553‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
agrin increase

Y553-p - MUSK (rat)
Modsite: RLHPNPMyQRMPLLL SwissProt
Orthologous residues
MUSK (human): Y554‑p, MUSK (mouse): Y553‑p, MUSK (rat): Y553‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal', C2.7 (myoblast)
Cellular systems studied:  cell lines, primary cultured cells
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE MUSK (rat)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
agrin increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced, phosphorylation
Comments:  promotes AChRb clustering and phosphorylation; promotes MuSK phosphorylation

Y576-p - MUSK (rat)
Modsite: YPRNNIEyVRDIGEG SwissProt
Orthologous residues
MUSK (human): Y577‑p, MUSK (mouse): Y576‑p, MUSK (rat): Y576‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal', C2.7 (myoblast)
Cellular systems studied:  cell lines, primary cultured cells
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE MUSK (rat)

Y750-p - MUSK (rat)
Modsite: FGLSRNIySADyyKA SwissProt
Orthologous residues
MUSK (human): Y751‑p, MUSK (mouse): Y750‑p, MUSK (rat): Y750‑p
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced, phosphorylation
Comments:  promotes AChRb clustering and phosphorylation; promotes MuSK phosphorylation

Y754-p - MUSK (rat)
Modsite: RNIySADyyKADGND SwissProt
Orthologous residues
MUSK (human): Y755‑p, MUSK (mouse): Y754‑p, MUSK (rat): Y754‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal', C2.7 (myoblast)
Cellular systems studied:  cell lines, primary cultured cells
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE MUSK (rat)
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced, phosphorylation
Comments:  promotes AChRb clustering and phosphorylation; promotes MuSK phosphorylation

Y755-p - MUSK (rat)
Modsite: NIySADyyKADGNDA SwissProt
Orthologous residues
MUSK (human): Y756‑p, MUSK (mouse): Y755‑p, MUSK (rat): Y755‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal', C2.7 (myoblast)
Cellular systems studied:  cell lines, primary cultured cells
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE MUSK (rat)
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced, phosphorylation
Comments:  promotes AChRb clustering and phosphorylation; promotes MuSK phosphorylation

Y812-p - MUSK (rat)
Modsite: MAHEEVIyYVRDGNI SwissProt
Orthologous residues
MUSK (human): Y813‑p, MUSK (mouse): Y812‑p, MUSK (rat): Y812‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal', C2.7 (myoblast)
Cellular systems studied:  cell lines, primary cultured cells
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE MUSK (rat)