Curated Information
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Home > Curated Information Page > PubMed Id: 9826708
Bardelli A, et al. (1998) Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth. Proc Natl Acad Sci U S A 95, 14379-83 9826708
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y1349-p - Met (human)
Modsite: stFIGEHyVHVNAty SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1349‑p, Met iso2 (human): Y1367‑p, Met (mouse): Y1347‑p, Met (rat): Y1350‑p
Characterization
Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey, mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Abl (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cell growth, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
GAB1 (human) Induces co-immunoprecipitation

Y1356-p - Met (human)
Modsite: yVHVNAtyVNVKCVA SwissProt Entrez-Gene
Orthologous residues
Met (human): Y1356‑p, Met iso2 (human): Y1374‑p, Met (mouse): Y1354‑p, Met (rat): Y1357‑p
Characterization
Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey, mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Abl (human)