Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.7
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 28591721
Zhou X, et al. (2017) Ginkgolide K attenuates neuronal injury after ischemic stroke by inhibiting mitochondrial fission and GSK-3β-dependent increases in mitochondrial membrane permeability. Oncotarget 8, 44682-44693 28591721
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
Download

S643-p - DRP1 (mouse)
Modsite: VPVARKLsAREQRDC SwissProt Entrez-Gene
Orthologous residues
DRP1 (human): S637‑p, DRP1 iso2 (human): S626‑p, DRP1 iso3 (human): S611‑p, DRP1 iso4 (human): S600‑p, DRP1 (mouse): S643‑p, DRP1 iso3 (mouse): S600‑p, DRP1 iso6 (mouse): S613‑p, DRP1 (rat): S656‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  brain, Neuro-2a (neuron)
Cellular systems studied:  cell lines, tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
deoxygenation decrease
ginkgolide K deoxygenation inhibit treatment-induced decrease
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  apoptosis, inhibited
Comments:  prevents its translocation to mitochondria

S9-p - GSK3B (mouse)
Modsite: SGRPRttsFAEsCKP SwissProt Entrez-Gene
Orthologous residues
GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S9‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  brain, Neuro-2a (neuron)
Cellular systems studied:  cell lines, tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
deoxygenation decrease
ginkgolide K deoxygenation inhibit treatment-induced decrease
ischemia/reperfusion decrease
ginkgolide K ischemia/reperfusion inhibit treatment-induced decrease