Curated Information
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Home > Curated Information Page > PubMed Id: 29030392
Bibli SI, et al. (2017) Hydrogen Sulfide Preserves Endothelial Nitric Oxide Synthase Function by Inhibiting Proline-Rich Kinase 2: Implications for Cardiomyocyte Survival and Cardioprotection. Mol Pharmacol 92, 718-730 29030392
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y657-p - eNOS (human)
Modsite: FGLGSRAyPHFCAFA SwissProt Entrez-Gene
Orthologous residues
eNOS (human): Y657‑p, eNOS (mouse): Y656‑p, eNOS (rat): Y656‑p, eNOS (rabbit): Y663‑p, eNOS (pig): Y659‑p, eNOS (cow): Y659‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), H9c2 (myoblast)
Cellular systems studied:  cell lines
Species studied:  human, rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
H2O2 increase
aminoxyacetic_acid increase
sodium sulfide H2O2 inhibit treatment-induced increase
sodium sulfide decrease

Y402-p - Pyk2 (human)
Modsite: CsIEsDIyAEIPDEt SwissProt Entrez-Gene
Orthologous residues
Pyk2 (human): Y402‑p, Pyk2 iso2 (human): Y402‑p, Pyk2 (mouse): Y402‑p, Pyk2 (rat): Y402‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), H9c2 (myoblast)
Cellular systems studied:  cell lines
Species studied:  human, rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
H2O2 increase
aminoxyacetic_acid increase
sodium sulfide H2O2 inhibit treatment-induced increase