Curated Information
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Home > Curated Information Page > PubMed Id: 23768697
Huang B, et al. (2013) Rosuvastatin-regulated post-translational phosphoproteome in human umbilical vein endothelial cells. Kaohsiung J Med Sci 29, 347-52 23768697
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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T211-p - Akt1 (human)
Modsite: NSRHPFLtALKYSFQ SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): T211‑p, Akt1 iso2 (human): T149‑p, Akt1 (mouse): T211‑p, Akt1 (rat): T211‑p, Akt1 (fruit fly): I327‑p, Akt1 (cow): T211‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  HUVEC (endothelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
rosuvastatin decrease

T291-p - Akt1 (human)
Modsite: kDGHIkItDFGLCkE SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): T291‑p, Akt1 iso2 (human): T229‑p, Akt1 (mouse): T291‑p, Akt1 (rat): T291‑p, Akt1 (fruit fly): A406‑p, Akt1 (cow): T291‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  HUVEC (endothelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
rosuvastatin increase

S633-p - eNOS (human)
Modsite: WRRKRKEssNtDsAG SwissProt Entrez-Gene
Orthologous residues
eNOS (human): S633‑p, eNOS (mouse): S632‑p, eNOS (rat): S632‑p, eNOS (rabbit): S639‑p, eNOS (pig): S635‑p, eNOS (cow): S635‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  HUVEC (endothelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
rosuvastatin increase

S1177-p - eNOS (human)
Modsite: TSRIRtQsFsLQERQ SwissProt Entrez-Gene
Orthologous residues
eNOS (human): S1177‑p, eNOS (mouse): S1176‑p, eNOS (rat): S1176‑p, eNOS (rabbit): S1183‑p, eNOS (pig): S1179‑p, eNOS (cow): S1179‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  HUVEC (endothelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
rosuvastatin increase

T71-p - G3BP-1 (human)
Modsite: kVMsQNFtNCHtkIR SwissProt Entrez-Gene
Orthologous residues
G3BP‑1 (human): T71‑p, G3BP‑1 (mouse): T71‑p, G3BP‑1 (rat): T71‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  HUVEC (endothelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
rosuvastatin increase

S232-p - G3BP-1 (human)
Modsite: EDAQKsssPAPADIA SwissProt Entrez-Gene
Orthologous residues
G3BP‑1 (human): S232‑p, G3BP‑1 (mouse): S231‑p, G3BP‑1 (rat): S231‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  HUVEC (endothelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
rosuvastatin increase