Curated Information
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Home > Curated Information Page > PubMed Id: 23776396
Kim Y, et al. (2013) 5,8-Dimethoxy-2-Nonylamino-Naphthalene-1,4-Dione Inhibits Vascular Smooth Muscle Cell Proliferation by Blocking Autophosphorylation of PDGF-Receptor β. Korean J Physiol Pharmacol 17, 203-8 23776396
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y578-p - PDGFRB (rat)
Modsite: VSSDGHEyIYVDPVQ SwissProt
Orthologous residues
PDGFRB (human): Y579‑p, PDGFRB (mouse): Y578‑p, PDGFRB (rat): Y578‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PDGFRB (rat)
Comments:  Autophosphorylation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF, serum_starvation increase
DMNQ PDGF, serum_starvation inhibit treatment-induced increase
AG1295 PDGF, serum_starvation inhibit treatment-induced increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Effect of modification (process):  cell cycle regulation, cell growth, induced, signaling pathway regulation
Comments:  downstream signaling pathway phosphorylation of STAT3, ERK1/2, Akt, and PLCG1 wasdetermined in PDGF-stimulated VSMCs

Y715-p - PDGFRB (rat)
Modsite: CPPSTELySNALPVG SwissProt
Orthologous residues
PDGFRB (human): Y716‑p, PDGFRB (mouse): Y715‑p, PDGFRB (rat): Y715‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PDGFRB (rat)
Comments:  Autophosphorylation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF, serum_starvation increase
DMNQ PDGF, serum_starvation inhibit treatment-induced increase
AG1295 PDGF, serum_starvation inhibit treatment-induced increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Effect of modification (process):  cell cycle regulation, cell growth, induced, signaling pathway regulation
Comments:  downstream signaling pathway phosphorylation of STAT3, ERK1/2, Akt, and PLCG1 wasdetermined in PDGF-stimulated VSMCs

Y750-p - PDGFRB (rat)
Modsite: SKDESVDyVPMLDMK SwissProt
Orthologous residues
PDGFRB (human): Y751‑p, PDGFRB (mouse): Y750‑p, PDGFRB (rat): Y750‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PDGFRB (rat)
Comments:  Autophosphorylation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF, serum_starvation increase
DMNQ PDGF, serum_starvation inhibit treatment-induced increase
AG1295 PDGF, serum_starvation inhibit treatment-induced increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Effect of modification (process):  cell cycle regulation, cell growth, induced, signaling pathway regulation
Comments:  downstream signaling pathway phosphorylation of STAT3, ERK1/2, Akt, and PLCG1 wasdetermined in PDGF-stimulated VSMCs

Y1020-p - PDGFRB (rat)
Modsite: PNETDNDyIIPLPDP SwissProt
Orthologous residues
PDGFRB (human): Y1021‑p, PDGFRB (mouse): Y1020‑p, PDGFRB (rat): Y1020‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PDGFRB (rat)
Comments:  Autophosphorylation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF, serum_starvation increase
DMNQ PDGF, serum_starvation inhibit treatment-induced increase
AG1295 PDGF, serum_starvation inhibit treatment-induced increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Effect of modification (process):  cell cycle regulation, cell growth, induced, signaling pathway regulation
Comments:  downstream signaling pathway phosphorylation of STAT3, ERK1/2, Akt, and PLCG1 wasdetermined in PDGF-stimulated VSMCs