Curated Information
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Home > Curated Information Page > PubMed Id: 23673667
Rohira AD, Chen CY, Allen JR, Johnson DL (2013) Covalent Small Ubiquitin-like Modifier (SUMO) Modification of Maf1 Protein Controls RNA Polymerase III-dependent Transcription Repression. J Biol Chem 288, 19288-95 23673667
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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K35-sm - MAF1 (human)
Modsite: RIESYSCkMAGDDKH SwissProt Entrez-Gene
Orthologous residues
MAF1 (human): K35‑sm, MAF1 (mouse): K35‑sm, MAF1 (rat): K35‑sm
Methods used to characterize site in vivo mutation of modification site, western blotting
Disease tissue studied:  brain cancer, glioblastoma, glioma
Relevant cell lines - cell types - tissues:  COS7 (fibroblast), HEK293T (epithelial), U87MG (glial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
SUMO LIGASE UBC9 (human) siRNA inhibition of enzyme
DESUMOYLASE SENP1 (human) siRNA inhibition of enzyme
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cell growth, inhibited, transcription, inhibited
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
POLR3A (human) Induces co-immunoprecipitation