Curated Information
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Home > Curated Information Page > PubMed Id: 23559008
Lynch JT, et al. (2013) TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells. Cell Death Dis 4, e573 23559008
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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K148-ac - Myc (human)
Modsite: AAkLVSEkLAsYQAA SwissProt Entrez-Gene
Orthologous residues
Myc (human): K148‑ac, Myc iso2 (human): K163‑ac, Myc (mouse): K149‑ac, Myc (rat): K149‑ac
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
ACETYLTRANSFERASE p300 (human) siRNA inhibition of enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TTC5 (human) increase siRNA increase (modestly)

K157-ac - Myc (human)
Modsite: AsYQAARkDSGsPNP SwissProt Entrez-Gene
Orthologous residues
Myc (human): K157‑ac, Myc iso2 (human): K172‑ac, Myc (mouse): K158‑ac, Myc (rat): K158‑ac
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
ACETYLTRANSFERASE p300 (human) siRNA inhibition of enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
siRNA no change compared to control p300 siRNA
TTC5 (human) no change compared to control

K323-ac - Myc (human)
Modsite: RkDYPAAkRVkLDsV SwissProt Entrez-Gene
Orthologous residues
Myc (human): K323‑ac, Myc iso2 (human): K338‑ac, Myc (mouse): K323‑ac, Myc (rat): K323‑ac