Chu J, Zheng H, Loh HH, Law PY (2008) Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins. Cell Signal 20, 1616-24 18558479

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S363-p - MOR-1 (rat) ▲

Modsite: stIEQQNsTRVRQNt SwissProt Entrez-Gene Orthologous residues MOR‑1 (human): S365‑p, MOR‑1 iso5 (human): S365‑p, MOR‑1 (mouse): S363‑p, MOR‑1 (rat): S363‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial), MEF (fibroblast) Cellular systems studied:  cell lines Species studied:  human, mouse Downstream Regulation Effect of modification (function):  receptor desensitization, altered

T370-p - MOR-1 (rat) ▲

Modsite: sTRVRQNtREHPsTA SwissProt Entrez-Gene Orthologous residues MOR‑1 (human): T372‑p, MOR‑1 iso5 (human): T372‑p, MOR‑1 (mouse): T370‑p, MOR‑1 (rat): T370‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial), MEF (fibroblast) Cellular systems studied:  cell lines Species studied:  human, mouse Downstream Regulation Effect of modification (function):  phosphorylation, receptor desensitization, altered

S375-p - MOR-1 (rat) ▲

Modsite: QNtREHPsTANTVDR SwissProt Entrez-Gene Orthologous residues MOR‑1 (human): S377‑p, MOR‑1 iso5 (human): S377‑p, MOR‑1 (mouse): S375‑p, MOR‑1 (rat): S375‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial), MEF (fibroblast) Cellular systems studied:  cell lines Species studied:  human, mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes morphine increase DAMGO increase Downstream Regulation Effect of modification (function):  receptor desensitization, altered