Lee CH, Lee CY, Tsai TS, Liou HH (2008) PKA-mediated phosphorylation is a novel mechanism for levetiracetam, an antiepileptic drug, activating ROMK1 channels. Biochem Pharmacol 76, 225-35 18547545

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S4-p - ROMK (human) ▲
Modsite: ____MNAsSRNVFDT SwissProt Entrez-Gene Orthologous residues ROMK (human): S4‑p, ROMK (mouse): ‑, ROMK (rat): S4‑p, ROMK iso2 (rat): ‑ Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  oocyte Cellular systems studied:  primary cells Species studied:  frog

S44-p - ROMK (human) ▲
Modsite: RQRARLVsKDGRCNI SwissProt Entrez-Gene Orthologous residues ROMK (human): S44‑p, ROMK (mouse): S25‑p, ROMK (rat): S44‑p, ROMK iso2 (rat): S25‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  oocyte Cellular systems studied:  primary cells Species studied:  frog

S183-p - ROMK (human) ▲
Modsite: GAILAKIsRPKKRAK SwissProt Entrez-Gene Orthologous residues ROMK (human): S183‑p, ROMK (mouse): S164‑p, ROMK (rat): S183‑p, ROMK iso2 (rat): S164‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  oocyte Cellular systems studied:  primary cells Species studied:  frog

T191-p - ROMK (human) ▲
Modsite: RPKKRAKtItFSKNA SwissProt Entrez-Gene Orthologous residues ROMK (human): T191‑p, ROMK (mouse): T172‑p, ROMK (rat): T191‑p, ROMK iso2 (rat): T172‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  oocyte Cellular systems studied:  primary cells Species studied:  frog

T193-p - ROMK (human) ▲
Modsite: KKRAKtItFSKNAVI SwissProt Entrez-Gene Orthologous residues ROMK (human): T193‑p, ROMK (mouse): T174‑p, ROMK (rat): T193‑p, ROMK iso2 (rat): T174‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  oocyte Cellular systems studied:  primary cells Species studied:  frog

S201-p - ROMK (human) ▲
Modsite: FSKNAVIskRGGKLC SwissProt Entrez-Gene Orthologous residues ROMK (human): S201‑p, ROMK (mouse): S182‑p, ROMK (rat): S201‑p, ROMK iso2 (rat): S182‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  oocyte Cellular systems studied:  primary cells Species studied:  frog

S219-p - ROMK (human) ▲

Modsite: RVANLRKsLLIGSHI SwissProt Entrez-Gene Orthologous residues ROMK (human): S219‑p, ROMK (mouse): S200‑p, ROMK (rat): S219‑p, ROMK iso2 (rat): S200‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  oocyte Cellular systems studied:  primary cells Species studied:  frog Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes Levetiracetam increase Downstream Regulation Effect of modification (function):  activity, induced

T234-p - ROMK (human) ▲
Modsite: YGKLLKTtVTPEGET SwissProt Entrez-Gene Orthologous residues ROMK (human): T234‑p, ROMK (mouse): T215‑p, ROMK (rat): T234‑p, ROMK iso2 (rat): T215‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  oocyte Cellular systems studied:  primary cells Species studied:  frog

S313-p - ROMK (human) ▲

Modsite: ATCQVRTsYVPEEVL SwissProt Entrez-Gene Orthologous residues ROMK (human): S313‑p, ROMK (mouse): S294‑p, ROMK (rat): S313‑p, ROMK iso2 (rat): S294‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  oocyte Cellular systems studied:  primary cells Species studied:  frog Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes Levetiracetam increase Downstream Regulation Effect of modification (function):  activity, induced