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Home > Curated Information Page > PubMed Id: 23711376
Bonet L, et al. (2013) Identification of functionally relevant phoshorylatable serine clusters in the cytoplasmic region of the human CD6 lymphocyte surface receptor. FEBS Lett 587, 2205-13 23711376
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S480-p - CD6 (human)
Modsite: PPPEDSDsGsDsDYE SwissProt Entrez-Gene
Orthologous residues
CD6 (human): S480‑p, CD6 (mouse): S476‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Disease tissue studied:  leukemia, T cell leukemia
Relevant cell lines - cell types - tissues:  COS7 (fibroblast), Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  green monkey, human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A1 (human)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heparin sodium decrease
phorbol_ester increase
Downstream Regulation
Effect of modification (function):  phosphorylation
Effect of modification (process):  signaling pathway regulation
Comments:  ERK1/2 phosphorylation, MAPK pathway activation

S482-p - CD6 (human)
Modsite: PEDSDsGsDsDYEHY SwissProt Entrez-Gene
Orthologous residues
CD6 (human): S482‑p, CD6 (mouse): S478‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Disease tissue studied:  leukemia, T cell leukemia
Relevant cell lines - cell types - tissues:  COS7 (fibroblast), Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  green monkey, human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A1 (human)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heparin sodium decrease
phorbol_ester increase
Downstream Regulation
Effect of modification (function):  phosphorylation
Effect of modification (process):  signaling pathway regulation
Comments:  ERK1/2 phosphorylation, MAPK pathway activation

S484-p - CD6 (human)
Modsite: DSDsGsDsDYEHYDF SwissProt Entrez-Gene
Orthologous residues
CD6 (human): S484‑p, CD6 (mouse): S480‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Disease tissue studied:  leukemia, T cell leukemia
Relevant cell lines - cell types - tissues:  COS7 (fibroblast), Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  green monkey, human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A1 (human)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heparin sodium decrease
phorbol_ester increase
Downstream Regulation
Effect of modification (function):  phosphorylation
Effect of modification (process):  signaling pathway regulation
Comments:  ERK1/2 phosphorylation, MAPK pathway activation

S505-p - CD6 (human)
Modsite: ALTTFYNsQRHRVtD SwissProt Entrez-Gene
Orthologous residues
CD6 (human): S505‑p, CD6 (mouse): S501‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heparin sodium decrease
phorbol_ester increase
Downstream Regulation
Effect of modification (function):  phosphorylation
Effect of modification (process):  signaling pathway regulation
Comments:  ERK1/2 phosphorylation, MAPK pathway activation

S560-p - CD6 (human)
Modsite: GPQYHPRsNsESsTs SwissProt Entrez-Gene
Orthologous residues
CD6 (human): S560‑p, CD6 (mouse): N556‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heparin sodium decrease
phorbol_ester increase
Downstream Regulation
Effect of modification (function):  phosphorylation
Effect of modification (process):  signaling pathway regulation
Comments:  ERK1/2 phosphorylation, MAPK pathway activation

S562-p - CD6 (human)
Modsite: QYHPRsNsESsTssG SwissProt Entrez-Gene
Orthologous residues
CD6 (human): S562‑p, CD6 (mouse): S558‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heparin sodium decrease
phorbol_ester increase
Downstream Regulation
Effect of modification (function):  phosphorylation
Effect of modification (process):  signaling pathway regulation
Comments:  ERK1/2 phosphorylation, MAPK pathway activation

S565-p - CD6 (human)
Modsite: PRsNsESsTssGEDY SwissProt Entrez-Gene
Orthologous residues
CD6 (human): S565‑p, CD6 (mouse): S561‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heparin sodium decrease
phorbol_ester increase
Downstream Regulation
Effect of modification (function):  phosphorylation
Effect of modification (process):  signaling pathway regulation
Comments:  ERK1/2 phosphorylation, MAPK pathway activation

S567-p - CD6 (human)
Modsite: sNsESsTssGEDYCN SwissProt Entrez-Gene
Orthologous residues
CD6 (human): S567‑p, CD6 (mouse): S563‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heparin sodium decrease
phorbol_ester increase
Downstream Regulation
Effect of modification (function):  phosphorylation
Effect of modification (process):  signaling pathway regulation
Comments:  ERK1/2 phosphorylation, MAPK pathway activation

S568-p - CD6 (human)
Modsite: NsESsTssGEDYCNS SwissProt Entrez-Gene
Orthologous residues
CD6 (human): S568‑p, CD6 (mouse): S564‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heparin sodium decrease
phorbol_ester increase
Downstream Regulation
Effect of modification (function):  phosphorylation
Effect of modification (process):  signaling pathway regulation
Comments:  ERK1/2 phosphorylation, MAPK pathway activation