Curated Information
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Home > Curated Information Page > PubMed Id: 23653351
Yogalingam G, Hwang S, Ferreira JC, Mochly-Rosen D (2013) Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Phosphorylation by Protein Kinase Cδ (PKCδ) Inhibits Mitochondria Elimination by Lysosomal-like Structures following Ischemia and Reoxygenation-induced Injury. J Biol Chem 288, 18947-60 23653351
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Click on the protein name to open the protein page, and on the RSD number to open the site page.

S241-p - GAPDH (human)
Modsite: RVPtANVsVVDLtCR SwissProt Entrez-Gene
Orthologous residues
GAPDH (human): S241‑p, GAPDH (mouse): S239‑p, GAPDH (rat): S239‑p

T246-p - GAPDH (human)
Modsite: NVsVVDLtCRLEkPA SwissProt Entrez-Gene
Orthologous residues
GAPDH (human): T246‑p, GAPDH (mouse): T244‑p, GAPDH (rat): T244‑p
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phosphopeptide mapping, western blotting
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  cell lines, tissue
Species studied:  mouse, rat
Enzymes shown to modify site in vitro
Type Enzyme
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCD (human) pharmacological inhibitor of upstream enzyme, modification site within consensus motif
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ischemia/reperfusion increase
deltaV1-1 ischemia/reperfusion inhibit treatment-induced increase