Curated Information
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Home > Curated Information Page > PubMed Id: 18558627
Feng J, et al. (2008) Phosphoproteome analysis of isoflurane-protected heart mitochondria: phosphorylation of adenine nucleotide translocator-1 on Tyr194 regulates mitochondrial function. Cardiovasc Res 80, 20-9 18558627
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S106-p - 1700021F05Rik (rat)
Modsite: KDADEEDsDEETSHL SwissProt Entrez-Gene
Orthologous residues
1700021F05Rik (mouse): S106‑p, 1700021F05Rik (rat): S106‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

S669-p - ACO2 (rat)
Modsite: DENyGEGsSREHAAL SwissProt Entrez-Gene
Orthologous residues
ACO2 (human): S669‑p, ACO2 (mouse): S669‑p, ACO2 (rat): S669‑p, ACO2 (pig): S669‑p, ACO2 (cow): S669‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

S101-p - AKAP1 (rat)
Modsite: TRQVRRRsEssGNLP SwissProt Entrez-Gene
Orthologous residues
AKAP1 (human): S105‑p, AKAP1 (mouse): S101‑p, AKAP1 (rat): S101‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

S333-p - BCKDH E1-alpha (rat)
Modsite: TYRIGHHstsDDSSA SwissProt Entrez-Gene
Orthologous residues
BCKDH E1‑alpha (human): S337‑p, BCKDH E1‑alpha (mouse): S334‑p, BCKDH E1‑alpha (rat): S333‑p, BCKDH E1‑alpha (pig): S339‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

S343-p - BCKDH E1-alpha (rat)
Modsite: DDSSAyRsVDEVNYW SwissProt Entrez-Gene
Orthologous residues
BCKDH E1‑alpha (human): S347‑p, BCKDH E1‑alpha (mouse): S344‑p, BCKDH E1‑alpha (rat): S343‑p, BCKDH E1‑alpha (pig): S349‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

S31-p - BCKDK (rat)
Modsite: SLSLRVRstsATDTH SwissProt Entrez-Gene
Orthologous residues
BCKDK (human): S31‑p, BCKDK (mouse): S31‑p, BCKDK (rat): S31‑p, BCKDK (pig): S31‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

T32-p - BCKDK (rat)
Modsite: LSLRVRstsATDTHH SwissProt Entrez-Gene
Orthologous residues
BCKDK (human): T32‑p, BCKDK (mouse): T32‑p, BCKDK (rat): T32‑p, BCKDK (pig): T32‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

S88-p - BNIP3 (rat)
Modsite: GEKNstLsEEDYIER SwissProt Entrez-Gene
Orthologous residues
BNIP3 (human): S160‑p, BNIP3 (mouse): S88‑p, BNIP3 (rat): S88‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

T194-p - ECHS1 (rat)
Modsite: LAMEMVLtGDRISAQ SwissProt Entrez-Gene
Orthologous residues
ECHS1 (human): T194‑p, ECHS1 (mouse): T194‑p, ECHS1 (rat): T194‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

S46-p - FAM82A2 (rat)
Modsite: QRHGRsQsLPNsLDY SwissProt Entrez-Gene
Orthologous residues
FAM82A2 (human): S46‑p, FAM82A2 (mouse): S46‑p, FAM82A2 (rat): S46‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

S57-p - GPAM (rat)
Modsite: KWKESLMsRKRPFVG SwissProt Entrez-Gene
Orthologous residues
GPAM (human): S57‑p, GPAM (mouse): S57‑p, GPAM (rat): S57‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

S695-p - GPAM (rat)
Modsite: sDEEDEDsDFGEEQR SwissProt Entrez-Gene
Orthologous residues
GPAM (human): S695‑p, GPAM (mouse): S694‑p, GPAM (rat): S695‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

S13-p - HSP27 (rat)
Modsite: VPFsLLRsPsWEPFR SwissProt Entrez-Gene
Orthologous residues
HSP27 (human): G13‑p, HSP27 (mouse): S13‑p, HSP27 (rat): S13‑p, HSP27 (pig): S13‑p, HSP27 (hamster): S13‑p, HSP27 (chicken): S13‑p, HSP27 (dog): S13‑p, HSP27 (cow): G13‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

S246-p - MDH2 (rat)
Modsite: kAKAGAGsATLSMAy SwissProt Entrez-Gene
Orthologous residues
MDH2 (human): S246‑p, MDH2 (mouse): S246‑p, MDH2 (rat): S246‑p, MDH2 (pig): S246‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

T26-p - PDE12 (rat)
Modsite: QRSPAEAttHEAVRA SwissProt Entrez-Gene
Orthologous residues
PDE12 (human): G27‑p, PDE12 iso2 (human): G27‑p, PDE12 (mouse): G26‑p, PDE12 (rat): T26‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

T27-p - PDE12 (rat)
Modsite: RSPAEAttHEAVRAM SwissProt Entrez-Gene
Orthologous residues
PDE12 (human): S28‑p, PDE12 iso2 (human): S28‑p, PDE12 (mouse): T27‑p, PDE12 (rat): T27‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

Y227-p - PDHA1 (rat)
Modsite: FICENNRyGMGtsVE SwissProt Entrez-Gene
Orthologous residues
PDHA1 (human): Y227‑p, PDHA1 iso2 (human): Y234‑p, PDHA1 iso4 (human): Y265‑p, PDHA1 (mouse): Y227‑p, PDHA1 (rat): Y227‑p, PDHA1 (pig): Y226‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

T231-p - PDHA1 (rat)
Modsite: NNRyGMGtsVERAAA SwissProt Entrez-Gene
Orthologous residues
PDHA1 (human): T231‑p, PDHA1 iso2 (human): T238‑p, PDHA1 iso4 (human): T269‑p, PDHA1 (mouse): T231‑p, PDHA1 (rat): T231‑p, PDHA1 (pig): T230‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

S232-p - PDHA1 (rat)
Modsite: NRyGMGtsVERAAAS SwissProt Entrez-Gene
Orthologous residues
PDHA1 (human): S232‑p, PDHA1 iso2 (human): S239‑p, PDHA1 iso4 (human): S270‑p, PDHA1 (mouse): S232‑p, PDHA1 (rat): S232‑p, PDHA1 (pig): S231‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

S293-p - PDHA1 (rat)
Modsite: TYRyHGHsMsDPGVs SwissProt Entrez-Gene
Orthologous residues
PDHA1 (human): S293‑p, PDHA1 iso2 (human): S300‑p, PDHA1 iso4 (human): S331‑p, PDHA1 (mouse): S293‑p, PDHA1 (rat): S293‑p, PDHA1 (pig): S292‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

S300-p - PDHA1 (rat)
Modsite: sMsDPGVsyRTREEI SwissProt Entrez-Gene
Orthologous residues
PDHA1 (human): S300‑p, PDHA1 iso2 (human): S307‑p, PDHA1 iso4 (human): S338‑p, PDHA1 (mouse): S300‑p, PDHA1 (rat): S300‑p, PDHA1 (pig): S299‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

S281-p - SCS-beta (rat)
Modsite: DAKINFDsNSAYRQK GenPept Entrez-Gene
Orthologous residues
SCS‑beta (human): S279‑p, SCS‑beta iso2 (human): S257‑p, SCS‑beta (mouse): S279‑p, SCS‑beta (rat): S281‑p, SCS‑beta (pig): S241‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

Y195-p - SLC25A4 (rat)
Modsite: RAAyFGVyDTAkGML SwissProt Entrez-Gene
Orthologous residues
SLC25A4 (human): Y195‑p, SLC25A4 (mouse): Y195‑p, SLC25A4 (rat): Y195‑p, SLC25A4 (pig): Y196‑p, SLC25A4 (cow): Y195‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ischemia/reperfusion decrease
isoflurane ischemia/reperfusion inhibit treatment-induced decrease

S94-p - TOMM70A (rat)
Modsite: KtPEGRAsPALGSGP SwissProt Entrez-Gene
Orthologous residues
TOMM70A (human): S91‑p, TOMM70A (mouse): S94‑p, TOMM70A (rat): S94‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria

S50-p - UQCRHL (rat)
Modsite: KARERLEsCDRRVSS SwissProt Entrez-Gene
Orthologous residues
UQCRHL (human): L52‑p, UQCRHL (mouse): L50‑p, UQCRHL (rat): S50‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  primary cells
Species studied:  rat
Comments:  heart mitochondria