Curated Information
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Home > Curated Information Page > PubMed Id: 23616576
Jang EJ, Park HR, Hong JH, Hwang ES (2013) Lysine 313 of T-box Is Crucial for Modulation of Protein Stability, DNA Binding, and Threonine Phosphorylation of T-bet. J Immunol 190, 5764-70 23616576
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T302-p - TBX21 (mouse)
Modsite: ETQFIAVtAYQNAEI SwissProt Entrez-Gene
Orthologous residues
TBX21 (human): T303‑p, TBX21 (mouse): T302‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Disease tissue studied:  lymphoma, T cell lymphoma
Relevant cell lines - cell types - tissues:  EL-4 (T lymphocyte), HEK293T (epithelial), T lymphocyte
Cellular systems studied:  cell lines
Species studied:  mouse

K313-ub - TBX21 (mouse)
Modsite: NAEITQLkIDNNPFA SwissProt Entrez-Gene
Orthologous residues
TBX21 (human): K314‑ub, TBX21 (mouse): K313‑ub
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Disease tissue studied:  lymphoma, T cell lymphoma
Relevant cell lines - cell types - tissues:  EL-4 (T lymphocyte), HEK293T (epithelial), T lymphocyte
Cellular systems studied:  cell lines
Species studied:  mouse
Downstream Regulation
Effect of modification (function):  molecular association, regulation, phosphorylation, protein stabilization
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
NFAT1 (human) Induces co-immunoprecipitation
Comments:  crucial for T302 phosphorylation