Curated Information
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Home > Curated Information Page > PubMed Id: 23589370
Liao JM, et al. (2013) IκB kinase β (IKKβ) inhibits p63 isoform γ (TAp63γ) transcriptional activity. J Biol Chem 288, 18184-93 23589370
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S43-p - p63 (human)
Modsite: yRSTMSQsTQtNEFL SwissProt Entrez-Gene
Orthologous residues
p63 (human): S43‑p, p63 iso2 (human): , p63 (mouse): S43‑p, p63 (rat): S43‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  lung cancer, non-small cell lung cancer
Relevant cell lines - cell types - tissues:  NCI-H1299 (pulmonary)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE IKKB (human) phosphopeptide analysis, transfection of wild-type enzyme
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  transcription, inhibited
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
p300 (human) Disrupts co-immunoprecipitation

S51-p - p63 (human)
Modsite: TQtNEFLsPEVFQHI SwissProt Entrez-Gene
Orthologous residues
p63 (human): S51‑p, p63 iso2 (human): , p63 (mouse): S51‑p, p63 (rat): S51‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  lung cancer, non-small cell lung cancer
Relevant cell lines - cell types - tissues:  NCI-H1299 (pulmonary)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE IKKB (human) phosphopeptide analysis, transfection of wild-type enzyme
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  transcription, inhibited
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
p300 (human) Disrupts co-immunoprecipitation