De Clercq S, et al. (2013) Nanobody-induced perturbation of LFA-1/L-plastin phosphorylation impairs MTOC docking, immune synapse formation and T cell activation. Cell Mol Life Sci 70, 909-22 23001012

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S745-p - ITGB2 (human) ▲

Modsite: FEkEKLksQWNNDNP SwissProt Entrez-Gene Orthologous residues ITGB2 (human): S745‑p, ITGB2 (mouse): S747‑p, ITGB2 (rat): S744‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  leukemia, T cell leukemia Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes LPL increase nanobodies that interfere with LPL cause decrease antibody increase

S5-p - L-plastin (human) ▲

Modsite: ___MARGsVsDEEMM SwissProt Entrez-Gene Orthologous residues L‑plastin (human): S5‑p, L‑plastin (mouse): S5‑p, L‑plastin (rat): S5‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  leukemia, T cell leukemia, lymphoma, Burkitt's lymphoma Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte), Raji (B lymphocyte) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes LPL increase nanobodies that interfere with LPL cause decrease antibody increase Downstream Regulation Effect of modification (function):  intracellular localization, molecular association, regulation Effect of modification (process):  cytoskeletal reorganization Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays ITGB2 (human) Induces co-immunoprecipitation Comments:  immune synapse formation