Curated Information
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Home > Curated Information Page > PubMed Id: 23436320
Sun Y, et al. (2014) Microcystin-LR induces protein phosphatase 2A alteration in a human liver cell line. Environ Toxicol 29, 1236-44 23436320
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y307-p - PPP2CA (human)
Modsite: VTRRtPDyFl_____ SwissProt Entrez-Gene
Orthologous residues
PPP2CA (human): Y307‑p, PPP2CA iso2 (human): Y253‑p, PPP2CA (mouse): Y307‑p, PPP2CA (rat): Y307‑p, PPP2CA (pig): Y307‑p, PPP2CA (cow): Y307‑p
Characterization
Methods used to characterize site in vivo modification-specific antibody, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  L02 (hepatic)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
microcystin-LR increase

L309-me - PPP2CA (human)
Modsite: RRtPDyFl_______ SwissProt Entrez-Gene
Orthologous residues
PPP2CA (human): L309‑me, PPP2CA iso2 (human): L255‑me, PPP2CA (mouse): L309‑me, PPP2CA (rat): L309‑me, PPP2CA (pig): L309‑me, PPP2CA (cow): L309‑me
Characterization
Methods used to characterize site in vivo modification-specific antibody, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  L02 (hepatic)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
microcystin-LR no change compared to control