Knotts TA, et al. (2001) Identification of a phosphorylation site in the hinge region of the human progesterone receptor and additional amino-terminal phosphorylation sites. J Biol Chem 276, 8475-83 11110801

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S20-p - PR (human) ▲

Modsite: HVAGGPPsPEVGsPL SwissProt Entrez-Gene Orthologous residues PR (human): S20‑p, PR iso2 (human): ‑, PR (mouse): S20‑p, PR (rat): S20‑p, PR (chicken): S13‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  SF9 Cellular systems studied:  cell lines Species studied:  insect Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes progestin_R5020 increase

S81-p - PR (human) ▲
Modsite: TQDQQsLsDVEGAys SwissProt Entrez-Gene Orthologous residues PR (human): S81‑p, PR iso2 (human): ‑, PR (mouse): S82‑p, PR (rat): S82‑p, PR (chicken): E71‑p Characterization Relevant cell lines - cell types - tissues:  T47D (breast cell) Cellular systems studied:  cell lines Species studied:  human

S102-p - PR (human) ▲

Modsite: GAGGSSssPPEKDSG SwissProt Entrez-Gene Orthologous residues PR (human): S102‑p, PR iso2 (human): ‑, PR (mouse): R103‑p, PR (rat): R102‑p, PR (chicken): S92‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  SF9 Cellular systems studied:  cell lines Species studied:  insect Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes progestin_R5020 increase

S130-p - PR (human) ▲

Modsite: GPGQSQPsPPACEVT SwissProt Entrez-Gene Orthologous residues PR (human): S130‑p, PR iso2 (human): ‑, PR (mouse): S131‑p, PR (rat): S130‑p, PR (chicken): A111‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  SF9 Cellular systems studied:  cell lines Species studied:  insect Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes progestin_R5020 increase

S162-p - PR (human) ▲

Modsite: PATQRVLsPLMSRSG SwissProt Entrez-Gene Orthologous residues PR (human): S162‑p, PR iso2 (human): ‑, PR (mouse): S163‑p, PR (rat): S162‑p, PR (chicken): A126‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mass spectrometry Relevant cell lines - cell types - tissues:  SF9, T47D (breast cell) Cellular systems studied:  cell lines Species studied:  human, insect Enzymes shown to modify site in vitro:  Type Enzyme KINASE CDK2 (human) Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes progestin_R5020 increase

S190-p - PR (human) ▲

Modsite: kVLPRGLsPARQLLL SwissProt Entrez-Gene Orthologous residues PR (human): S190‑p, PR iso2 (human): S26‑p, PR (mouse): S191‑p, PR (rat): S190‑p, PR (chicken): ‑ Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  SF9 Cellular systems studied:  cell lines Species studied:  insect Enzymes shown to modify site in vitro:  Type Enzyme KINASE CDK2 (human) Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes progestin_R5020 increase

S213-p - PR (human) ▲

Modsite: SGAPVKPsPQAAAVE SwissProt Entrez-Gene Orthologous residues PR (human): S213‑p, PR iso2 (human): S49‑p, PR (mouse): S214‑p, PR (rat): S213‑p, PR (chicken): G158‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling Relevant cell lines - cell types - tissues:  T47D (breast cell) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE CDK2 (human) Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes progestin_R5020 increase

S294-p - PR (human) ▲
Modsite: APMAPGRsPLATTVM SwissProt Entrez-Gene Orthologous residues PR (human): S294‑p, PR iso2 (human): S130‑p, PR (mouse): S294‑p, PR (rat): S293‑p, PR (chicken): G219‑p Characterization Relevant cell lines - cell types - tissues:  T47D (breast cell) Cellular systems studied:  cell lines Species studied:  human

S345-p - PR (human) ▲

Modsite: AFAPPRSsPCASSTP SwissProt Entrez-Gene Orthologous residues PR (human): S345‑p, PR iso2 (human): S181‑p, PR (mouse): S345‑p, PR (rat): S344‑p, PR (chicken): S259‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  SF9 Cellular systems studied:  cell lines Species studied:  insect Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes progestin_R5020 increase

S400-p - PR (human) ▲
Modsite: GAEAsARsPRSYLVA SwissProt Entrez-Gene Orthologous residues PR (human): S400‑p, PR iso2 (human): S236‑p, PR (mouse): S400‑p, PR (rat): S399‑p, PR (chicken): ‑ Characterization Relevant cell lines - cell types - tissues:  T47D (breast cell) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE CDK2 (human)

S676-p - PR (human) ▲

Modsite: LSQRFTFsPGQDIQL SwissProt Entrez-Gene Orthologous residues PR (human): S676‑p, PR iso2 (human): S512‑p, PR (mouse): S669‑p, PR (rat): S666‑p, PR (chicken): S529‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  SF9 Cellular systems studied:  cell lines Species studied:  insect Enzymes shown to modify site in vitro:  Type Enzyme KINASE CDK2 (human) Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes progestin_R5020 increase