Jorge-Finnigan A, et al. (2017) Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules. J Biol Chem 292, 14092-14107 28637871

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S19-p - TH iso3 (human) ▲

Modsite: KGFRRAVsELDAKQA SwissProt Entrez-Gene Orthologous residues TH (human): S19‑p, TH iso2 (human): S19‑p, TH iso3 (human): S19‑p, TH iso4 (human): S19‑p, TH (mouse): S19‑p, TH (rat): S19‑p, TH (cow): S19‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Disease tissue studied:  adrenal cancer, pheochromocytoma, neuroblastoma Relevant cell lines - cell types - tissues:  293 (epithelial), PC-12 (chromaffin), SH-SY5Y (neural crest) Cellular systems studied:  cell lines

S31-p - TH iso3 (human) ▲

Modsite: KQAEAIMsPRFIGRR SwissProt Entrez-Gene Orthologous residues TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Disease tissue studied:  adrenal cancer, pheochromocytoma, neuroblastoma Relevant cell lines - cell types - tissues:  293 (epithelial), PC-12 (chromaffin), SH-SY5Y (neural crest) Cellular systems studied:  cell lines Downstream Regulation Effect of modification (function):  intracellular localization, molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays SNCA (mouse) Induces co-immunoprecipitation SLC18A2 (mouse) Induces co-immunoprecipitation Comments:  associates with vesicles, transport to neurite terminals

S40-p - TH iso3 (human) ▲

Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene Orthologous residues TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Disease tissue studied:  adrenal cancer, pheochromocytoma, neuroblastoma Relevant cell lines - cell types - tissues:  293 (epithelial), PC-12 (chromaffin), SH-SY5Y (neural crest) Cellular systems studied:  cell lines