Curated Information
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Home > Curated Information Page > PubMed Id: 23446420
Atwood SX, et al. (2013) GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas. Nature 494, 484-8 23446420
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S243-p - GLI1 (human)
Modsite: DCRWDGCsQEFDSQE SwissProt Entrez-Gene
Orthologous residues
GLI1 (human): S243‑p, GLI1 (mouse): S246‑p, GLI1 (rat): S243‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Disease tissue studied:  BCC
Relevant cell lines - cell types - tissues:  epidermal
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCI (human) pharmacological inhibitor of upstream enzyme, co-immunoprecipitation

T304-p - GLI1 (human)
Modsite: GEKPHKCtFEGCRKS SwissProt Entrez-Gene
Orthologous residues
GLI1 (human): T304‑p, GLI1 (mouse): T307‑p, GLI1 (rat): T304‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Disease tissue studied:  BCC
Relevant cell lines - cell types - tissues:  epidermal
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCI (human) pharmacological inhibitor of upstream enzyme, co-immunoprecipitation