Curated Information
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Home > Curated Information Page > PubMed Id: 23396967
González-Sancho JM, et al. (2013) Functional Consequences of Wnt-induced Dishevelled 2 Phosphorylation in Canonical and Noncanonical Wnt Signaling. J Biol Chem 288, 9428-37 23396967
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S591-p - DVL2 (human)
Modsite: QHSEGSRssGstRsD SwissProt Entrez-Gene
Orthologous residues
DVL2 (human): S591‑p, DVL2 (mouse): S591‑p, DVL2 (rat): S591‑p

S592-p - DVL2 (human)
Modsite: HSEGSRssGstRsDG SwissProt Entrez-Gene
Orthologous residues
DVL2 (human): S592‑p, DVL2 (mouse): S592‑p, DVL2 (rat): S592‑p

S594-p - DVL2 (human)
Modsite: EGSRssGstRsDGGA SwissProt Entrez-Gene
Orthologous residues
DVL2 (human): S594‑p, DVL2 (mouse): S594‑p, DVL2 (rat): S594‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Disease tissue studied:  bone cancer, Ewing's sarcoma
Relevant cell lines - cell types - tissues:  293 (epithelial), Rat2 (fibroblast), TC-32
Cellular systems studied:  cell lines
Species studied:  human, rat
Downstream Regulation
Effect of modification (process):  cytoskeletal reorganization, transcription, inhibited
Comments:  neurite outgrowth

T595-p - DVL2 (human)
Modsite: GSRssGstRsDGGAG SwissProt Entrez-Gene
Orthologous residues
DVL2 (human): T595‑p, DVL2 (mouse): T595‑p, DVL2 (rat): T595‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Disease tissue studied:  bone cancer, Ewing's sarcoma
Relevant cell lines - cell types - tissues:  293 (epithelial), Rat2 (fibroblast), TC-32
Cellular systems studied:  cell lines
Species studied:  human, rat
Downstream Regulation
Effect of modification (process):  cytoskeletal reorganization, transcription, inhibited
Comments:  neurite outgrowth

S597-p - DVL2 (human)
Modsite: RssGstRsDGGAGRT SwissProt Entrez-Gene
Orthologous residues
DVL2 (human): S597‑p, DVL2 (mouse): S597‑p, DVL2 (rat): S597‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Disease tissue studied:  bone cancer, Ewing's sarcoma
Relevant cell lines - cell types - tissues:  293 (epithelial), Rat2 (fibroblast), TC-32
Cellular systems studied:  cell lines
Species studied:  human, rat
Downstream Regulation
Effect of modification (process):  cytoskeletal reorganization, transcription, inhibited
Comments:  neurite outgrowth

S591-p - DVL2 (mouse)
Modsite: QHSEGSRssGstRsD SwissProt Entrez-Gene
Orthologous residues
DVL2 (human): S591‑p, DVL2 (mouse): S591‑p, DVL2 (rat): S591‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK1D (human)

S592-p - DVL2 (mouse)
Modsite: HSEGSRssGstRsDG SwissProt Entrez-Gene
Orthologous residues
DVL2 (human): S592‑p, DVL2 (mouse): S592‑p, DVL2 (rat): S592‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK1D (human)

S594-p - DVL2 (mouse)
Modsite: EGSRssGstRsDGGA SwissProt Entrez-Gene
Orthologous residues
DVL2 (human): S594‑p, DVL2 (mouse): S594‑p, DVL2 (rat): S594‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK1D (human)

T595-p - DVL2 (mouse)
Modsite: GSRssGstRsDGGAG SwissProt Entrez-Gene
Orthologous residues
DVL2 (human): T595‑p, DVL2 (mouse): T595‑p, DVL2 (rat): T595‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK1D (human)

S597-p - DVL2 (mouse)
Modsite: RssGstRsDGGAGRT SwissProt Entrez-Gene
Orthologous residues
DVL2 (human): S597‑p, DVL2 (mouse): S597‑p, DVL2 (rat): S597‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK1D (human)