Johnson KE, et al. (2013) Phosphorylation on Ser-279 and Ser-282 of connexin43 regulates endocytosis and gap junction assembly in pancreatic cancer cells. Mol Biol Cell 24, 715-33 23363606

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S279-p - GJA1 (rat) ▲

Modsite: SSPTAPLsPMsPPGY SwissProt Entrez-Gene Orthologous residues GJA1 (human): S279‑p, GJA1 (mouse): S279‑p, GJA1 (rat): S279‑p, GJA1 (rabbit): S279‑p, GJA1 (pig): S279‑p, GJA1 (hamster): S279‑p, GJA1 (cow): S280‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting Disease tissue studied:  pancreatic cancer, pancreatic carcinoma Relevant cell lines - cell types - tissues:  BxPC-3 (pancreatic) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  endocytosis, induced Comments:  Phosphorylation of S279 impairs Cx43 assembly into gap junctions.

S282-p - GJA1 (rat) ▲

Modsite: TAPLsPMsPPGYkLV SwissProt Entrez-Gene Orthologous residues GJA1 (human): S282‑p, GJA1 (mouse): S282‑p, GJA1 (rat): S282‑p, GJA1 (rabbit): S282‑p, GJA1 (pig): S282‑p, GJA1 (hamster): S282‑p, GJA1 (cow): S283‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting Disease tissue studied:  pancreatic cancer, pancreatic carcinoma Relevant cell lines - cell types - tissues:  BxPC-3 (pancreatic) Cellular systems studied:  cell lines Species studied:  human