Curated Information
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Home > Curated Information Page > PubMed Id: 23318434
Sanchez-Arévalo Lobo VJ, et al. (2013) Dual regulation of Myc by Abl. Oncogene 32, 5261-71 23318434
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y12-p - Myc (human)
Modsite: VsFtNRNyDLDyDSV SwissProt Entrez-Gene
Orthologous residues
Myc (human): Y12‑p, Myc iso2 (human): Y27‑p, Myc (mouse): Y12‑p, Myc (rat): Y12‑p

Y16-p - Myc (human)
Modsite: NRNyDLDyDSVQPyF SwissProt Entrez-Gene
Orthologous residues
Myc (human): Y16‑p, Myc iso2 (human): Y31‑p, Myc (mouse): Y16‑p, Myc (rat): Y16‑p

Y22-p - Myc (human)
Modsite: DyDSVQPyFYCDEEE SwissProt Entrez-Gene
Orthologous residues
Myc (human): Y22‑p, Myc iso2 (human): Y37‑p, Myc (mouse): Y22‑p, Myc (rat): Y22‑p

Y32-p - Myc (human)
Modsite: CDEEENFyQQQQQSE SwissProt Entrez-Gene
Orthologous residues
Myc (human): Y32‑p, Myc iso2 (human): Y47‑p, Myc (mouse): Y32‑p, Myc (rat): Y32‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Abl (human) transfection of wild-type enzyme, co-immunoprecipitation Also phosphorylates one or more of residues Y12/16/22

T58-p - Myc (human)
Modsite: kkFELLPtPPLsPsR SwissProt Entrez-Gene
Orthologous residues
Myc (human): T58‑p, Myc iso2 (human): T73‑p, Myc (mouse): T58‑p, Myc (rat): T58‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  transcription, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIN1 (human) Induces co-immunoprecipitation

S62-p - Myc (human)
Modsite: LLPtPPLsPsRRsGL SwissProt Entrez-Gene
Orthologous residues
Myc (human): S62‑p, Myc iso2 (human): S77‑p, Myc (mouse): S62‑p, Myc (rat): S62‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  transcription, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIN1 (human) Induces co-immunoprecipitation

Y74-p - Myc (human)
Modsite: sGLCsPSyVAVtPFs SwissProt Entrez-Gene
Orthologous residues
Myc (human): Y74‑p, Myc iso2 (human): Y89‑p, Myc (mouse): Y74‑p, Myc (rat): Y74‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Abl (human) transfection of wild-type enzyme, co-immunoprecipitation Also phosphorylates one or more of residues Y12/16/22
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  cell growth, induced
Comments:  pY74 is localized to the cytoplasm, and is critical for maximal Myc activity in cellular transformation.
Associated Diseases
Diseases Alterations Comments
ovarian cancer increased