Curated Information
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Chen SC, Kennedy BK, Lampe PD (2013) Phosphorylation of connexin43 on S279/282 may contribute to laminopathy-associated conduction defects. Exp Cell Res 319, 888-96 23261543
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S279-p - GJA1 (mouse)
Modsite: SsPtAPLsPMsPPGy SwissProt Entrez-Gene
Orthologous residues
GJA1 (human): S279‑p, GJA1 (mouse): S279‑p, GJA1 (rat): S279‑p, GJA1 (rabbit): S279‑p, GJA1 (pig): S279‑p, GJA1 (hamster): S279‑p, GJA1 (cow): S280‑p
Characterization
Methods used to characterize site in vivo immunoassay, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  heart, MEF (fibroblast)
Cellular systems studied:  cell lines, tissue
Species studied:  mouse
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ERK1 (mouse) co-immunoprecipitation, modification site within consensus motif
KINASE ERK2 (mouse) co-immunoprecipitation, modification site within consensus motif
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lamin A/C (mouse) decrease

S282-p - GJA1 (mouse)
Modsite: tAPLsPMsPPGykLV SwissProt Entrez-Gene
Orthologous residues
GJA1 (human): S282‑p, GJA1 (mouse): S282‑p, GJA1 (rat): S282‑p, GJA1 (rabbit): S282‑p, GJA1 (pig): S282‑p, GJA1 (hamster): S282‑p, GJA1 (cow): S283‑p
Characterization
Methods used to characterize site in vivo immunoassay, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  heart, MEF (fibroblast)
Cellular systems studied:  cell lines, tissue
Species studied:  mouse
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ERK1 (mouse) co-immunoprecipitation, modification site within consensus motif
KINASE ERK2 (mouse) co-immunoprecipitation, modification site within consensus motif
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
lamin A/C (mouse) decrease