Curated Information
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Home > Curated Information Page > PubMed Id: 23051746
Joiner ML, et al. (2012) CaMKII determines mitochondrial stress responses in heart. Nature 491, 269-73 23051746
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S56-p - MCU (mouse)
Modsite: TAHQRPAsWQSVGAA SwissProt Entrez-Gene
Orthologous residues
MCU (human): S57‑p, MCU iso2 (human): S57‑p, MCU iso3 (human): S8‑p, MCU (mouse): S56‑p, MCU (rat): S56‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  mitoplasts
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CAMK2A (human) modification site within consensus motif, transfection of wild-type enzyme, co-immunoprecipitation, transfection of inactive enzyme

S91-p - MCU (mouse)
Modsite: VISVRLPsRRERCQF SwissProt Entrez-Gene
Orthologous residues
MCU (human): S92‑p, MCU iso2 (human): S92‑p, MCU iso3 (human): S43‑p, MCU (mouse): S91‑p, MCU (rat): S91‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  mitoplasts
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CAMK2A (human) modification site within consensus motif, transfection of wild-type enzyme, co-immunoprecipitation, transfection of inactive enzyme