Chen YJ, et al. (2013) Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor. J Neurochem 124, 189-99 23106126

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

Download

S356-p - MOR-1 (rat) ▲

Modsite: EFCIPTsstIEQQNs SwissProt Entrez-Gene Orthologous residues MOR‑1 (human): S358‑p, MOR‑1 iso5 (human): S358‑p, MOR‑1 (mouse): S356‑p, MOR‑1 (rat): S356‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes morphine increase DAMGO increase

T357-p - MOR-1 (rat) ▲

Modsite: FCIPTsstIEQQNsT SwissProt Entrez-Gene Orthologous residues MOR‑1 (human): N359‑p, MOR‑1 iso5 (human): N359‑p, MOR‑1 (mouse): T357‑p, MOR‑1 (rat): T357‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes morphine increase DAMGO increase

S363-p - MOR-1 (rat) ▲

Modsite: stIEQQNsTRVRQNt SwissProt Entrez-Gene Orthologous residues MOR‑1 (human): S365‑p, MOR‑1 iso5 (human): S365‑p, MOR‑1 (mouse): S363‑p, MOR‑1 (rat): S363‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCA (human) Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays ARR3 (human) Induces ARRB2 (human) Induces in vitro

T370-p - MOR-1 (rat) ▲

Modsite: sTRVRQNtREHPsTA SwissProt Entrez-Gene Orthologous residues MOR‑1 (human): T372‑p, MOR‑1 iso5 (human): T372‑p, MOR‑1 (mouse): T370‑p, MOR‑1 (rat): T370‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE CAMK2A (human) Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays ARR3 (human) Induces ARRB2 (human) Induces in vitro

S375-p - MOR-1 (rat) ▲

Modsite: QNtREHPsTANTVDR SwissProt Entrez-Gene Orthologous residues MOR‑1 (human): S377‑p, MOR‑1 iso5 (human): S377‑p, MOR‑1 (mouse): S375‑p, MOR‑1 (rat): S375‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE GRK2 (human) Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes morphine increase DAMGO increase Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays ARR3 (human) Induces ARRB2 (human) Induces in vitro