Curated Information
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Home > Curated Information Page > PubMed Id: 17283176
Aziz MH, Manoharan HT, Verma AK (2007) Protein kinase C epsilon, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3. Cancer Res 67, 1385-94 17283176
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T58-p - Myc (mouse)
Modsite: KKFELLPtPPLsPsR SwissProt Entrez-Gene
Orthologous residues
Myc (human): T58‑p, Myc iso2 (human): T73‑p, Myc (mouse): T58‑p, Myc (rat): T58‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
UV increase
UV PKCE (mouse) augment treatment-induced increase

S62-p - Myc (mouse)
Modsite: LLPtPPLsPsRRsGL SwissProt Entrez-Gene
Orthologous residues
Myc (human): S62‑p, Myc iso2 (human): S77‑p, Myc (mouse): S62‑p, Myc (rat): S62‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
UV increase
UV PKCE (mouse) augment treatment-induced increase

Y705-p - STAT3 (mouse)
Modsite: DPGsAAPyLktkFIC SwissProt Entrez-Gene
Orthologous residues
STAT3 (human): Y705‑p, STAT3 iso2 (human): Y704‑p, STAT3 iso3 (human): Y705‑p, STAT3 (mouse): Y705‑p, STAT3 iso2 (mouse): Y705‑p, STAT3 iso3 (mouse): Y704‑p, STAT3 (rat): Y705‑p, STAT3 (cow): Y705‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
UV increase
UV PKCE (mouse) augment treatment-induced increase

S727-p - STAT3 (mouse)
Modsite: NtIDLPMsPRTLDSL SwissProt Entrez-Gene
Orthologous residues
STAT3 (human): S727‑p, STAT3 iso2 (human): S726‑p, STAT3 iso3 (human): , STAT3 (mouse): S727‑p, STAT3 iso2 (mouse): , STAT3 iso3 (mouse): S726‑p, STAT3 (rat): S727‑p, STAT3 (cow): S727‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  skin, skin [PKCE (mouse)]
Cellular systems studied:  tissue
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCE (mouse)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCE (mouse) microscopy-colocalization, co-immunoprecipitation, genetic knockout/knockin of upstream enzyme, genetic transfer of wild-type enzyme, pharmacological activator of upstream enzyme, phospho-antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
UV increase
UV PKCE (mouse) augment treatment-induced increase