Curated Information
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Home > Curated Information Page > PubMed Id: 18438430
Zhang Y, Wang Z, Li X, Magnuson NS (2008) Pim kinase-dependent inhibition of c-Myc degradation. Oncogene 27, 4809-19 18438430
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T58-p - Myc (mouse)
Modsite: KKFELLPtPPLsPsR SwissProt Entrez-Gene
Orthologous residues
Myc (human): T58‑p, Myc iso2 (human): T73‑p, Myc (mouse): T58‑p, Myc (rat): T58‑p

S62-p - Myc (mouse)
Modsite: LLPtPPLsPsRRsGL SwissProt Entrez-Gene
Orthologous residues
Myc (human): S62‑p, Myc iso2 (human): S77‑p, Myc (mouse): S62‑p, Myc (rat): S62‑p

S329-p - Myc (mouse)
Modsite: AkRAKLDsGRVLKQI SwissProt Entrez-Gene
Orthologous residues
Myc (human): S329‑p, Myc iso2 (human): S344‑p, Myc (mouse): S329‑p, Myc (rat): S329‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Disease tissue studied:  leukemia, chronic myelogenous leukemia
Relevant cell lines - cell types - tissues:  COS (fibroblast), K562 (erythroid)
Cellular systems studied:  cell lines
Species studied:  green monkey
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Pim1 (human)
KINASE Pim2 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Pim1 (human) transfection of wild-type enzyme, transfection of inactive enzyme
KINASE Pim2 (human) transfection of wild-type enzyme, transfection of inactive enzyme
Downstream Regulation
Effect of modification (function):  protein stabilization
Effect of modification (process):  cell growth, altered, transcription, induced
Comments:  enhances the oncogenic transforming activity of c-Myc