Curated Information
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Home > Curated Information Page > PubMed Id: 17064352
Bobrovskaya L, et al. (2007) Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis. J Neurochem 100, 479-89 17064352
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T202-p - ERK1 (human)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): T202‑p, ERK1 iso2 (human): T202‑p, ERK1 iso3 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nicotine increase increase at 10 minutes, return to basal at 24 hours
histamine increase increase at 10 minutes, return to basal at 24 hours
angiotensin_2 increase increase at 10 minutes, return to basal at 24 hours
phorbol_ester increase increase at 10 minutes, return to basal at 24 hours

Y204-p - ERK1 (human)
Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): Y204‑p, ERK1 iso2 (human): Y204‑p, ERK1 iso3 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nicotine increase increase at 10 minutes, return to basal at 24 hours
histamine increase increase at 10 minutes, return to basal at 24 hours
angiotensin_2 increase increase at 10 minutes, return to basal at 24 hours
phorbol_ester increase increase at 10 minutes, return to basal at 24 hours

T185-p - ERK2 (human)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p, ERK2 (cow): T185‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nicotine increase increase at 10 minutes, return to basal at 24 hours
histamine increase increase at 10 minutes, return to basal at 24 hours
angiotensin_2 increase increase at 10 minutes, return to basal at 24 hours
phorbol_ester increase increase at 10 minutes, return to basal at 24 hours

Y187-p - ERK2 (human)
Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p, ERK2 (cow): Y187‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nicotine increase increase at 10 minutes, return to basal at 24 hours
histamine increase increase at 10 minutes, return to basal at 24 hours
angiotensin_2 increase increase at 10 minutes, return to basal at 24 hours
phorbol_ester increase increase at 10 minutes, return to basal at 24 hours

S19-p - TH (cow)
Modsite: KGFRRAVsELDAKQA SwissProt Entrez-Gene
Orthologous residues
TH (human): S19‑p, TH iso2 (human): S19‑p, TH iso3 (human): S19‑p, TH iso4 (human): S19‑p, TH (mouse): S19‑p, TH (rat): S19‑p, TH (cow): S19‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nicotine increase increase at 10 minutes, return to basal at 24 hours
histamine increase increase at 10 minutes, return to basal at 24 hours
angiotensin_2 increase increase at 10 minutes, return to basal at 24 hours

S31-p - TH (cow)
Modsite: KQAEAIMsPRFVGRR SwissProt Entrez-Gene
Orthologous residues
TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nicotine increase increase at 10 minutes, return to basal at 24 hours
histamine increase increase at 10 minutes, return to basal at 24 hours
angiotensin_2 increase increase at 10 minutes, return to basal at 24 hours
phorbol_ester increase increase at 10 minutes, return to basal at 24 hours

S40-p - TH (cow)
Modsite: RFVGRRQsLIQDARK SwissProt Entrez-Gene
Orthologous residues
TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nicotine increase at 10 min, 24 hr, and 48 hr
imipramine nicotine inhibit treatment-induced increase
histamine increase at 10 min and 24 hr
angiotensin_2 increase at 10 min and 24 hr
bradykinin no change compared to control
muscarine no change compared to control
phorbol_ester increase at 10 min and 24 hr
Go_6983 phorbol_ester inhibit treatment-induced increase