Avramovich-Tirosh Y, et al. (2007) Therapeutic targets and potential of the novel brain- permeable multifunctional iron chelator-monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease. J Neurochem 100, 490-502 17144902

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

Download

T286-p - CAMK2A (rat) ▲

Modsite: sCMHRQEtVDCLkkF SwissProt Entrez-Gene Orthologous residues CAMK2A (human): T286‑p, CAMK2A iso2 (human): T286‑p, CAMK2A (mouse): T286‑p, CAMK2A iso2 (mouse): ‑, CAMK2A (rat): T286‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, phosphoamino acid analysis, phosphopeptide mapping Relevant cell lines - cell types - tissues:  'neuron, hippocampal, CA1 pyramidal'-brain Cellular systems studied:  primary cultured cells Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes Ca(2+) increase Downstream Regulation Effect of modification (function):  molecular association, regulation, phosphorylation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays CAMK2B (rat) Induces phosphorylation MARCKS (rat) Induces phosphorylation co-immunoprecipitation CAMK2A (rat) Induces phosphorylation SYN1 (rat) Induces molecular association, regulation co-immunoprecipitation

T287-p - CAMK2B (rat) ▲

Modsite: sMMHRQEtVECLkkF SwissProt Entrez-Gene Orthologous residues CAMK2B (human): T287‑p, CAMK2B iso2 (human): T287‑p, CAMK2B iso3 (human): T287‑p, CAMK2B iso4 (human): T287‑p, CAMK2B iso6 (human): T287‑p, CAMK2B iso8 (human): T287‑p, CAMK2B (mouse): T287‑p, CAMK2B iso2 (mouse): T158‑p, CAMK2B iso3 (mouse): T287‑p, CAMK2B (rat): T287‑p, CAMK2B iso2 (rat): ‑, CAMK2B iso3 (rat): T287‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, phosphoamino acid analysis, phosphopeptide mapping Relevant cell lines - cell types - tissues:  'neuron, hippocampal, CA1 pyramidal'-brain Cellular systems studied:  primary cultured cells Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes Ca(2+) increase Downstream Regulation Effect of modification (function):  molecular association, regulation, phosphorylation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays CAMK2B (rat) Induces phosphorylation CAMK2A (rat) Induces phosphorylation SYN1 (rat) Induces molecular association, regulation co-immunoprecipitation MARCKS (rat) Induces phosphorylation co-immunoprecipitation