Curated Information
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Home > Curated Information Page > PubMed Id: 17261647
Long C, et al. (2007) FK506 binding protein 12/12.6 depletion increases endothelial nitric oxide synthase threonine 495 phosphorylation and blood pressure. Hypertension 49, 569-76 17261647
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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T494-p - eNOS (mouse)
Modsite: AGITRKKtFKEVANA SwissProt Entrez-Gene
Orthologous residues
eNOS (human): T495‑p, eNOS (mouse): T494‑p, eNOS (rat): T494‑p, eNOS (rabbit): T501‑p, eNOS (pig): T497‑p, eNOS (cow): T497‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  aorta
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Go_6976 no change compared to control
rapamycin increase
rapamycin, Go_6976 rapamycin inhibit treatment-induced increase
ryanodine no change compared to control
ryanodine, rapamycin rapamycin inhibit treatment-induced increase
Go_6976 FKBP12 (mouse) FKBP14 (mouse) inhibit treatment-induced increase
FKBP14 (mouse) increase FKBP12,6 -/-
ryanodine FKBP14 (mouse) FKBP14 (mouse) inhibit treatment-induced increase

S657-p - PKCA (mouse)
Modsite: QsDFEGFsyVNPQFV SwissProt Entrez-Gene
Orthologous residues
PKCA (human): S657‑p, PKCA (mouse): S657‑p, PKCA (rat): S657‑p, PKCA (cow): S657‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  aorta
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ryanodine no change compared to control
rapamycin no change compared to control
ryanodine, rapamycin rapamycin, ryanodine decrease
FKBP12 (mouse) increase
ryanodine FKBP12 (mouse) FKBP12 (mouse) inhibit treatment-induced increase