Curated Information
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Home > Curated Information Page > PubMed Id: 12231407
Zhang Z, et al. (2002) Calcitonin induces dephosphorylation of Pyk2 and phosphorylation of focal adhesion kinase in osteoclasts. Bone 31, 359-65 12231407
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y402-p - Pyk2 (human)
Modsite: CsIEsDIyAEIPDEt SwissProt Entrez-Gene
Orthologous residues
Pyk2 (human): Y402‑p, Pyk2 iso2 (human): Y402‑p, Pyk2 (mouse): Y402‑p, Pyk2 (rat): Y402‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Cellular systems studied:  cell lines, primary cultured cells
Species studied:  human, mouse, rabbit
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
calcitonin decrease osteoclasts
phorbol_ester increase osteoclasts
ionomycin decrease osteoclasts
calcitonin increase C1a-HEK cells
phorbol_ester increase C1a-HEK cells
ionomycin increase C1a-HEK cells