Konopleva M, et al. (2006) Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell 10, 375-88 17097560

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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T69-p - Bcl-2 (human) ▲

Modsite: SRDPVARtsPLQtPA SwissProt Entrez-Gene Orthologous residues Bcl‑2 (human): T69‑p, Bcl‑2 (mouse): T69‑p, Bcl‑2 (rat): T69‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  leukemia Relevant cell lines - cell types - tissues:  NSF/N1.H7 (myeloid) Cellular systems studied:  cell lines Species studied:  mouse Downstream Regulation Effect of modification (process):  apoptosis, inhibited

S70-p - Bcl-2 (human) ▲

Modsite: RDPVARtsPLQtPAA SwissProt Entrez-Gene Orthologous residues Bcl‑2 (human): S70‑p, Bcl‑2 (mouse): S70‑p, Bcl‑2 (rat): S70‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  leukemia Relevant cell lines - cell types - tissues:  NSF/N1.H7 (myeloid) Cellular systems studied:  cell lines Species studied:  mouse Downstream Regulation Effect of modification (process):  apoptosis, inhibited

S87-p - Bcl-2 (human) ▲

Modsite: AAAGPALsPVPPVVH SwissProt Entrez-Gene Orthologous residues Bcl‑2 (human): S87‑p, Bcl‑2 (mouse): S84‑p, Bcl‑2 (rat): S84‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  leukemia Relevant cell lines - cell types - tissues:  NSF/N1.H7 (myeloid) Cellular systems studied:  cell lines Species studied:  mouse Downstream Regulation Effect of modification (process):  apoptosis, inhibited