Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.0.1
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 23007395
Hukkelhoven E, et al. (2012) Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma. J Biol Chem 287, 38523-30 23007395
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.

Y76-p - p21Cip1 (mouse)
Modsite: SLGLPKVyLsPGSRS SwissProt Entrez-Gene
Orthologous residues
p21Cip1 (human): Y77‑p, p21Cip1 (mouse): Y76‑p, p21Cip1 (rat): Y76‑p, p21Cip1 (dog): S45‑p
Methods used to characterize site in vivo mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  DF1 (fibroblast), HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Abl (human)
Downstream Regulation
Effect of modification (process):  carcinogenesis, induced, cell growth, induced
Associated Diseases
Diseases Alterations Comments
glioma PDGF induced glioma in mice