Christoforides C, et al. (2012) PKD Controls αvβ3 Integrin Recycling and Tumor Cell Invasive Migration through Its Substrate Rabaptin-5. Dev Cell 23, 560-72 22975325

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S407-p - RABEP1 (human) ▲

Modsite: DGLRRAQstDsLGts SwissProt Entrez-Gene Orthologous residues RABEP1 (human): S407‑p, RABEP1 iso2 (human): S407‑p, RABEP1 (mouse): S407‑p, RABEP1 (rat): S407‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, western blotting Disease tissue studied:  breast cancer Relevant cell lines - cell types - tissues:  293 (epithelial), 3T3 (fibroblast), MDA-MB-231 (breast cell) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PRKD1 (human) Downstream Regulation Effect of modification (function):  receptor recycling, induced Effect of modification (process):  cell motility, induced Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays Rab4 (human) Induces cell motility, induced microscopy-colocalization, co-immunoprecipitation Comments:  EGFR and integrin recycling; persistent directional migration; invasion into Matrigel